奥哌咪酮

• 常用名: 奥哌咪酮
• 英文名: 2H-Benzimidazol-2-one,1,3-dihydro-1-[1-(2-phenoxyethyl)-4-piperidinyl]
• CAS号: 5322-53-2
• 分子量: 337.41600
• 密度: 1.208g/cm3
• 沸点: N/A
• 分子式: C₂₀H₂₃N₃O₂
• 熔点: N/A
• 闪点: N/A

奥哌咪酮用途

Oxiperomide 是具有口服活性的多巴胺阻断剂。

奥哌咪酮名称

• 中文名: 奥哌咪酮
• 英文名: 3-[1-(2-phenoxyethyl)piperidin-4-yl]-1H-benzimidazol-2-one

奥哌咪酮生物活性

• 描述: Oxiperomide 是具有口服活性的多巴胺阻断剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. S Gerhardt, et al. SCH 23390 dissociated from conventional neuroleptics in apomorphine climbing and primate acute dyskinesia models. Life Sci. 1985 Dec 23;37(25):2355-63.

奥哌咪酮物理化学性质

• 密度: 1.208g/cm3
• 分子式: C₂₀H₂₃N₃O₂
• 分子量: 337.41600
• 精确质量: 337.17900
• PSA: 50.26000
• LogP: 2.98340
• InChIKey: NVDBBGBUTKLRSN-UHFFFAOYSA-N
• SMILES: O=c1[nH]c2ccccc2n1C1CCN(CCOc2ccccc2)CC1
• 折射率: 1.607
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:3

  4.可旋转化学键数量:5

  5.互变异构体数量:2

  6.拓扑分子极性表面积:44.8

  7.重原子数量:25

  8.表面电荷:0

  9.复杂度:444

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

奥哌咪酮安全信息

• 海关编码: 2933990090

奥哌咪酮海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

奥哌咪酮靶点实验

查看更多实验

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Bas... 来源：Broad Institute 靶标：N/A External Id：2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Prima... 来源：NCGC 靶标：apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] External Id：AMA1100

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] External Id：ABHD4_INH_FP_1536_1X%INH PRUN

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奥哌咪酮英文别名

• Peromide
• Oxiperomida
• 1-[1-(2-phenoxyethyl)piperidin-4-yl]-1,3-dihydro-2h-benzimidazol-2-one
• Oxiperomide
• R-4714
• 1-[1-(2-phenoxy-ethyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one
• Oxiperomidum
• 1-(1-(2-phenoxyethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
• Oxiperomide (USAN/INN)