异银杏双黄酮

• 常用名: 异银杏双黄酮
• 英文名: ISOGINKGETIN
• CAS号: 548-19-6
• 分子量: 566.511
• 密度: 1.5±0.1 g/cm3
• 沸点: 843.6±65.0 °C at 760 mmHg
• 分子式: C₃₂H₂₂O₁₀
• 熔点: 355ºC
• 闪点: 280.2±27.8 °C

异银杏双黄酮用途

Isoginkgetin是MMP9的抑制剂,也是Pre-mRNA Splicing的抑制剂。

异银杏双黄酮名称

• 中文名: 异银杏双黄酮
• 英文名: isoginkgetin
• 中文别名: 异银杏素

异银杏双黄酮生物活性

• 描述: Isoginkgetin是MMP9的抑制剂,也是Pre-mRNA Splicing的抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> MMP
  研究领域 >> 癌症
  天然产物 >> 黄酮类化合物
• 参考文献:

  [1]. Yoon SO et al. Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther. 2006 Nov;5(11):2666-75.

  [2]. O'Brien K et al. The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J Biol Chem. 2008 Nov 28;283(48):33147-54.

  [3]. Liu G et al. Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase.J Endocrinol. 2007 Sep;194(3):569-78.

异银杏双黄酮物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 843.6±65.0 °C at 760 mmHg
• 熔点: 355ºC
• 分子式: C₃₂H₂₂O₁₀
• 分子量: 566.511
• 闪点: 280.2±27.8 °C
• 精确质量: 566.121277
• PSA: 159.80000
• LogP: 5.24
• InChIKey: HUOOMAOYXQFIDQ-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2cc(=O)c3c(O)cc(O)c(-c4cc(-c5cc(=O)c6c(O)cc(O)cc6o5)ccc4OC)c3o2)cc1
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.714
• 储存条件: -20°C

异银杏双黄酮靶点实验

查看更多实验

实验名称：Potentiation of 5-FU-induced cytotoxicity in human HCT-116 cells assessed as reductio... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5236489

实验名称：Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability at 1... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5236488

实验名称：Downregulation of MDM2 protein expression in human HCT-116 cells at 10 uM incubated f... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5236491

实验名称：Upregulation of p53 protein expression in human HCT-116 cells at 10 uM incubated for ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5236490

实验名称：Induction of ferroptosis in human HCT-116 cells assessed as reduction in GSH content ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5236485

实验名称：Induction of ferroptosis in human HCT-116 cells assessed as increase in iron content ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5236484

实验名称：Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability at 1... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5236487

实验名称：Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability at 1... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5236486

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：Induction of mitochondrial membrane potential depolarization in human HCT-116 cells a... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5236481

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异银杏双黄酮英文别名

• 8-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
• 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
• ISOGINKGETIN
• 4',4'''-di-O-methylamentoflavone