三苔色酸

• 常用名: 三苔色酸
• 英文名: Gyrophoric acid
• CAS号: 548-89-0
• 分子量: 468.410
• 密度: 1.5±0.1 g/cm3
• 沸点: 693.9±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₀O₁₀
• 熔点: N/A
• 闪点: 238.5±25.0 °C

三苔色酸用途

回旋磷酸是地衣种群中很好的紫外线滤光片。回旋磷酸具有DPPH自由基清除活性,IC50值为105.75µg/ml[1][2]。

三苔色酸名称

• 中文名: 石耳酸
• 英文名: 4-[4-(2,4-dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoyl]oxy-2-hydroxy-6-methylbenzoic acid

三苔色酸生物活性

• 描述: 回旋磷酸是地衣种群中很好的紫外线滤光片。回旋磷酸具有DPPH自由基清除活性,IC50值为105.75µg/ml[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: 旋磷酸(200 μM)导致24小时后卵巢癌细胞A2780线粒体膜电位显著降低 h长时间暴露于HT-29结肠腺癌细胞,但不暴露于HT-29结肠腺癌细胞。回旋磷酸显著抑制细胞生长并影响Bcl-2、Bax和Hsp70蛋白的表达,但仅在A375黑色素瘤细胞中浓度较高。回旋磷酸对HeLa细胞的处理清楚地表明ROS的产生和凋亡是细胞死亡的形式。此外,回旋磷酸处理介导的DNA损伤和应激/存活蛋白如p38MAPK、Erk1/2和Akt的活性变化证实了促凋亡潜能[2]。
• 参考文献:

  [1]. Kosanic M, et al. Biological activities and chemical composition of lichens from Serbia. EXCLI J. 2014;13:1226-1238. Published 2014 Nov 18.

  [2]. Goga M, et al. Oxidative stress mediated by gyrophoric acid from the lichen Umbilicaria hirsuta affected apoptosis and stress/survival pathways in HeLa cells. BMC Complement Altern Med. 2019;19(1):221. Published 2019 Aug 19.

三苔色酸物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 693.9±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₀O₁₀
• 分子量: 468.410
• 闪点: 238.5±25.0 °C
• 精确质量: 468.105652
• PSA: 170.82000
• LogP: 6.62
• InChIKey: ATQPZSQVWCPVGV-UHFFFAOYSA-N
• SMILES: Cc1cc(OC(=O)c2c(C)cc(OC(=O)c3c(C)cc(O)cc3O)cc2O)cc(O)c1C(=O)O
• 外观性状: 粉末
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.686
• 储存条件: 2-8℃，干燥，密闭

三苔色酸安全信息

• 危害码 (欧洲): Xi

三苔色酸靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Effect on uncoupled photosystem 2 of spinach chloroplast assessed as inhibition of el... 来源：ChEMBL 靶标：N/A External Id：CHEMBL970895

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Effect on uncoupled photosystem 2 of spinach leaves chloroplast assessed as inhibitio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL970894

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Effect on uncoupled photosystem 2 of spinach chloroplast assessed as inhibition of el... 来源：ChEMBL 靶标：N/A External Id：CHEMBL970897

实验名称：Effect on uncoupled photosystem 2 of spinach chloroplast assessed as inhibition of el... 来源：ChEMBL 靶标：N/A External Id：CHEMBL970896

实验名称：Effect on uncoupled photosystem 2 of spinach leaves chloroplast assessed as inhibitio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL970891

实验名称：Phytogrowth-inhibitory activity against Echinochloa crusgalli assessed as inhibition ... 来源：ChEMBL 靶标：Echinochloa crus-galli External Id：CHEMBL970890

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

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三苔色酸英文别名

• Benzoic acid, 4-[(2,4-dihydroxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-, 4-carboxy-3-hydroxy-5-methylphenyl ester
• 4-({4-[(2,4-Dihydroxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methylbenzoyl}oxy)-2-hydroxy-6-methylbenzoic acid
• Gyrophoric acid
• Gyrophorsaeure
• p-Triorsellinsaeure