甘草苷

• 常用名: 甘草苷
• 英文名: Liquiritin
• CAS号: 551-15-5
• 分子量: 418.39
• 密度: 1.5±0.1 g/cm3
• 沸点: 746.8±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₂O₉
• 熔点: 212 °C
• 闪点: 265.9±26.4 °C

甘草苷用途

Liquiritin 是一种从甘草中得到的黄酮类化合物,为抗氧化剂,具有神经保护、抗癌、抗炎的活性。

甘草苷名称

• 中文名: 甘草苷
• 英文名: liquiritin
• 中文别名: 甘草甙 | 甘草黄苷,甘草黄酮,甘草根亭,甘草素-4′-Β-葡萄糖苷 | 甘草黄苷 | 甘草甙；甘草素-4’-O-葡萄糖苷

甘草苷生物活性

• 描述: Liquiritin 是一种从甘草中得到的黄酮类化合物,为抗氧化剂,具有神经保护、抗癌、抗炎的活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 靶点实验:

  Liquiritin (100 µM) increases glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells[1].

• 参考文献:

  [1]. Nakatani Y, et al. Neuroprotective effect of liquiritin as an antioxidant via an increase in glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells. Eur J Pharmacol. 2017 Nov 15;815:381-390.

甘草苷物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 746.8±60.0 °C at 760 mmHg
• 熔点: 212 °C
• 分子式: C₂₁H₂₂O₉
• 分子量: 418.39
• 闪点: 265.9±26.4 °C
• 精确质量: 418.126373
• PSA: 145.91000
• LogP: 0.61
• InChIKey: DEMKZLAVQYISIA-ZRWXNEIDSA-N
• SMILES: O=C1CC(c2ccc(OC3OC(CO)C(O)C(O)C3O)cc2)Oc2cc(O)ccc21
• 外观性状: 固体;White to Light yellow to Light orange powder to crystal
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.670
• 储存条件: 2-8°C

甘草苷安全信息

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 29389090

甘草苷靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as redu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4186604

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Antitussive activity in po dosed ammonia liquor-induced cough ICR mouse model assesse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4186605

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as redu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4186601

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as redu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4186602

实验名称：Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as redu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4186612

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甘草苷英文别名

• Liquiritoside
• (2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2,3-dihydrochromen-4-one
• Likviritin
• 4',7-Dihydroxyflavanone 4'-(β-D-glucoside)
• (S)-2-(4-(β-D-Glucopyranosyloxy)phenyl)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one
• 4',7-Dihydroxyflavanone 4'-(β-D-glucopyranoside)
• 4-[(2S)-7-Hydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]phenyl β-D-glucopyranoside
• Liquiritin
• liquiritigenin 4'-O-glucoside
• Liquiritigenin-4'-O-glucoside