PCAF-IN-2

• 常用名: PCAF-IN-2
• 英文名: PCAF-IN-2
• CAS号: 56173-05-8
• 分子量: 268.20
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₀H₇F₃N₆
• 熔点: N/A
• 闪点: N/A

PCAF-IN-2用途

PCAF-IN-2(化合物17)是一种有效的PCAF抑制剂,IC50值为5.31µM。PCAF-IN-2具有抗肿瘤活性。CAF-IN-2诱导细胞凋亡并将细胞周期阻滞在G2/M期[1]。

PCAF-IN-2名称

• 英文名: PCAF-IN-2

PCAF-IN-2生物活性

• 描述: PCAF-IN-2(化合物17)是一种有效的PCAF抑制剂,IC50值为5.31µM。PCAF-IN-2具有抗肿瘤活性。CAF-IN-2诱导细胞凋亡并将细胞周期阻滞在G2/M期[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白乙酰转移酶
• 靶点实验:

  PCAF:5.31 μM (IC50)

• 体外研究: PCAF-IN-2对HePG2、MCF-7、PC3、HCT-116细胞的IC50分别为3.06、5.69、7.56、2.83µM,显示出抗肿瘤活性[1]。PCAF-IN-2(10µM；24 h)诱导HePG2细胞凋亡并将细胞周期阻滞在G2/M期[1]。
• 参考文献:

  [1]. Turky A, et al. Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorg Chem. 2020 Aug;101:104019.

PCAF-IN-2物理化学性质

• 分子式: C₁₀H₇F₃N₆
• 分子量: 268.20

PCAF-IN-2靶点实验

查看更多实验

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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