Terminolic acid

• 常用名: Terminolic acid
• 英文名: Terminolic acid
• CAS号: 564-13-6
• 分子量: 504.69900
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₄₈O₆
• 熔点: N/A
• 闪点: N/A

Terminolic acid用途

Terminolic acid 是一种从 Combretum racemosum 中分离出的五环三萜糖苷。Terminolic acid 可以通过结合 IL-1β 和 IL-6 的受体活性位点来抑制促炎细胞因子,并且可以通过结合 IL4 受体的结合位点来增强抗炎细胞因子。Terminolic acid 还表现出中等的抗菌活性。

Terminolic acid名称

• 英文名: (4aS,6aR,6aS,6bR,8R,9R,10R,11R,12aR,14bR)-8,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid

Terminolic acid生物活性

• 描述: Terminolic acid 是一种从 Combretum racemosum 中分离出的五环三萜糖苷。Terminolic acid 可以通过结合 IL-1β 和 IL-6 的受体活性位点来抑制促炎细胞因子,并且可以通过结合 IL4 受体的结合位点来增强抗炎细胞因子。Terminolic acid 还表现出中等的抗菌活性。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Gossan DPA, et, al. Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum. Fitoterapia. 2016 Apr;110:89-95.

  [2]. Legiawati L, et, al. In silico study of Centella asiatica active compounds as anti-inflammatory agent by decreasing Il-1 and Il-6 activity, promoting Il-4 activity. /J. Pharm. Sci. & Res. Vol. 10(9), 2018, 2142-2147.

Terminolic acid物理化学性质

• 分子式: C₃₀H₄₈O₆
• 分子量: 504.69900
• 精确质量: 504.34500
• PSA: 118.22000
• LogP: 4.14760
• InChIKey: IDQVFXZQPGAVAM-GGVBUJAJSA-N
• SMILES: CC1(C)CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC43C)C2C1
• 外观性状: 固体
• 储存条件: 2-8°C， 密封， 干燥

Terminolic acid靶点实验

查看更多实验

实验名称：Antifungal activity against Candida albicans clinical isolate by two-fold serial micr... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL3077509

实验名称：Inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate prei... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3871032

实验名称：Inhibition of Saccharomyces cerevisiae fatty acid synthase 来源：ChEMBL 靶标：N/A External Id：CHEMBL943598

实验名称：Inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate at 2... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3871033

实验名称：Inhibition of rat intestinal alpha-glucosidase using PNPG as substrate at 200 uM afte... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3871034

实验名称：Antifungal activity against Cryptococcus neoformans ATCC 90113 来源：ChEMBL 靶标：Cryptococcus neoformans External Id：CHEMBL943600

实验名称：Inhibition of pig pancreas alpha-amylase using potato starch as substrate at 200 uM a... 来源：ChEMBL 靶标：Pancreatic alpha-amylase External Id：CHEMBL3871035

实验名称：Antifungal activity against Candida albicans ATCC 90028 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL943599

实验名称：Antifungal activity against Candida albicans ATCC 90028 by two-fold serial microdilut... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL3077507

实验名称：Antifungal activity against Candida albicans MTCC 1637 by two-fold serial microdiluti... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL3077508

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Terminolic acid英文别名

• Olean-12-en-28-oic acid,2,3,6,23-tetrahydroxy-,(2alpha,3beta,4alpha,6beta)
• 2,3,6,23-Tetrahydroxyolean-12-en-28-oic acid (2alpha,3beta,4alpha,6beta)
• Terminolic acid