金丝菌素

• 常用名: 金丝菌素
• 英文名: Aureothricin
• CAS号: 574-95-8
• 分子量: 242.31800
• 密度: 1.48g/cm3
• 沸点: 479.1ºC at 760 mmHg
• 分子式: C₉H₁₀N₂O₂S₂
• 熔点: N/A
• 闪点: 243.6ºC

金丝菌素用途

Aureothricin 是一种二硫吡咯酮类 (DTP) 抗生素,首次是从链霉菌中获得,具有相对广谱的抗菌活性。Aureothricin 能抑制人脐静脉内皮细胞 (HUVECs) 与玻连蛋白的黏附。

金丝菌素名称

• 中文名: 金丝菌素
• 英文名: N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)propanamide

金丝菌素生物活性

• 描述: Aureothricin 是一种二硫吡咯酮类 (DTP) 抗生素,首次是从链霉菌中获得,具有相对广谱的抗菌活性。Aureothricin 能抑制人脐静脉内皮细胞 (HUVECs) 与玻连蛋白的黏附。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  Bacteral[1]

• 参考文献:

  [1]. Li B, et al. Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. Nat Prod Rep. 2014 Jul;31(7):905-23.

金丝菌素物理化学性质

• 密度: 1.48g/cm3
• 沸点: 479.1ºC at 760 mmHg
• 分子式: C₉H₁₀N₂O₂S₂
• 分子量: 242.31800
• 闪点: 243.6ºC
• 精确质量: 242.01800
• PSA: 111.07000
• LogP: 2.61110
• InChIKey: UGZYFXMSMFMTSM-UHFFFAOYSA-N
• SMILES: CCC(=O)Nc1c2sscc-2n(C)c1=O
• 折射率: 1.694

金丝菌素靶点实验

查看更多实验

实验名称：Antimicrobial activity against Listeria monocytogenes CIP 82110 after 24 to 48 hrs by... 来源：ChEMBL 靶标：Listeria monocytogenes External Id：CHEMBL1166878

实验名称：Antimicrobial activity against Saccharomyces cerevisiae ATCC 4226 after 48 to 72 hrs ... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL1168898

实验名称：Antimicrobial activity against Staphylococcus aureus CIP 7625 after 24 to 48 hrs by a... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1166877

实验名称：Antimicrobial activity against Candida albicans IPA 200 after 48 to 72 hrs by agar di... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL1168897

实验名称：Antimicrobial activity against Micrococcus luteus ATCC 9314 after 24 to 48 hrs by aga... 来源：ChEMBL 靶标：Micrococcus luteus External Id：CHEMBL1166876

实验名称：Antimicrobial activity against Fusarium graminearum after 48 to 72 hrs by agar diluti... 来源：ChEMBL 靶标：Fusarium graminearum External Id：CHEMBL1168896

实验名称：Antimicrobial activity against Bacillus coagulans CIP 6625 after 24 to 48 hrs by agar... 来源：ChEMBL 靶标：Heyndrickxia coagulans External Id：CHEMBL1166875

实验名称：Antimicrobial activity against Fusarium culmorum after 48 to 72 hrs by agar dilution ... 来源：ChEMBL 靶标：Fusarium culmorum External Id：CHEMBL1168895

实验名称：Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 to 48 hrs by agar... 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL1166874

实验名称：Antimicrobial activity against Fusarium equiseti after 48 to 72 hrs by agar dilution ... 来源：ChEMBL 靶标：Fusarium equiseti External Id：CHEMBL1168894

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金丝菌素英文别名

• propionopyrrothine
• Aureothricin
• Anzeothricin
• 4-methyl-6-propionylamino-4H-[1,2]dithiolo[4,3-b]pyrrol-5-one
• N-(4-methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-propionamide
• N-(4-Methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-propionamid
• Farcinicin
• Propiopyvothine
• Aurethricin