替米哌隆

• 常用名: 替米哌隆
• 英文名: Timiperone
• CAS号: 57648-21-2
• 分子量: 397.50900
• 密度: 1.31
• 沸点: 560.8ºC at 760 mmHg
• 分子式: C₂₂H₂₄FN₃OS
• 熔点: 201-203ºC
• 闪点: 293ºC

替米哌隆用途

Timiperone 对大脑多巴胺 D2 受体 有很强的亲和力。Timiperone 具有抗精神病活性,并抑制刻板行为。Timiperone 可用于精神分裂症的研究

替米哌隆名称

• 中文名: 替米哌隆
• 英文名: 1-(4-fluorophenyl)-4-[4-(2-sulfanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]butan-1-one
• 中文别名: 4-[4-(2,3-二氢-2-硫酮-1H-苯并咪唑-1-基)-1-哌啶基]-1-(4-氟苯基)-1-丁酮

替米哌隆生物活性

• 描述: Timiperone 对大脑多巴胺 D2 受体 有很强的亲和力。Timiperone 具有抗精神病活性,并抑制刻板行为。Timiperone 可用于精神分裂症的研究
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 靶点实验:

  dopamine D2 receptor[3]

• 参考文献:

  [1]. Sudo K, et al. Disposition of timiperone, 4'-fluoro-4-[4-(2-thioxo-1-benzimidazolinyl)piperidino]butyrophenone, a neuroleptic, in the rat on repeated oral dosage. Xenobiotica. 1981 Oct;11(10):685-91.

  [2]. Kariya T, et al. A comparison of the clinical effects of timiperone, a new butyrophenone derivative, and haloperidol on schizophrenia using a double-blind technique. J Int Med Res. 1983;11(2):66-77.

  [3]. Inada, K., et al. First-Generation Antipsychotics as a Bridge to Second-Generation Antipsychotics in the Japanese Pharmaceutical Industry: Mosapramine, Timiperone, Zotepine, and Nemonapride. NeuroPsychopharmacotherapy. Springer, Cham. (2021).

替米哌隆物理化学性质

• 密度: 1.31
• 沸点: 560.8ºC at 760 mmHg
• 熔点: 201-203ºC
• 分子式: C₂₂H₂₄FN₃OS
• 分子量: 397.50900
• 闪点: 293ºC
• 精确质量: 397.16200
• PSA: 73.12000
• LogP: 5.07590
• InChIKey: YDLQKLWVKKFPII-UHFFFAOYSA-N
• SMILES: O=C(CCCN1CCC(n2c(=S)[nH]c3ccccc32)CC1)c1ccc(F)cc1
• 折射率: 1.664

替米哌隆毒性和生态

替米哌隆靶点实验

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替米哌隆英文别名

• EINECS 260-880-9
• DD 3480
• Tolopelon
• timiperone