非诺班

更新时间：2024-01-09 04:22:46

非诺班结构式	常用名	非诺班	英文名	Fenobam
	CAS号	57653-26-6	分子量	266.68400
	密度	1.47 g/cm3	沸点	N/A
	分子式	C₁₁H₁₁ClN₄O₂	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS06	信号词	Danger

非诺班用途

Fenobam 是一种选择性、口服活性、非竞争性的 mGluR5 拮抗剂,其作用于变构调节位点 (在大鼠和人重组 mGlu5 受体上的 Kd 值分别 54 nM 和 31 nM)。Fenobam 具有反向激动剂活性,其阻断 mGlu5 受体活性,IC50为 84 nM。 Fenobam 具有抗焦虑活性。

中文名	非诺班
英文名	fenobam
中文别名	苯脲咪唑酮
英文别名	更多

描述	Fenobam 是一种选择性、口服活性、非竞争性的 mGluR5 拮抗剂,其作用于变构调节位点 (在大鼠和人重组 mGlu5 受体上的 Kd 值分别 54 nM 和 31 nM)。Fenobam 具有反向激动剂活性,其阻断 mGlu5 受体活性,IC50为 84 nM。 Fenobam 具有抗焦虑活性。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体研究领域 >> 神经疾病
靶点	rat mGluR5:54 nM (Kd) human mGluR5:31 nM (Kd)
参考文献	[1]. Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. [2]. Laura F, et al. The Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Fenobam: Pharmacokinetics, Side Effects, and Analgesic Effects in Healthy Human Subjects.bioRxiv 391383;

密度	1.47 g/cm3
分子式	C₁₁H₁₁ClN₄O₂
分子量	266.68400
精确质量	266.05700
PSA	73.80000
LogP	1.12690
折射率	1.668
储存条件	2-8°C

非诺班MSDS英文版

符号	GHS06
信号词	Danger
危害声明	H300
警示性声明	Missing Phrase - N15.00950417
个人防护装备	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危险品运输编码	UN 2811 6.1 / PGIII

Pharmacophoric features of drugs with guanylurea moiety: an electronic structure analysis.

J. Mol. Model. 19(4) , 1865-74, (2013)

Several therapeutically important compounds contain guanylurea (GU) moiety. The appropriate tautomeric state of these species has not been explored, preliminary studies indicated that the traditional ...

Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.

J. Neurosci. 35 , 11125-32, (2015)

Exacerbated mRNA translation during brain development has been linked to autism spectrum disorders (ASDs). Deletion of the eukaryotic initiation factor 4E (eIF4E)-binding protein 2 gene (Eif4ebp2), en...

Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.

Bioorg. Med. Chem. 23 , 3040-58, (2015)

Metabotropic glutamate receptor 5 (mGlu5) is a biological target implicated in major neurological and psychiatric disorders. In the present study, we have investigated structural determinants of the i...

Mcn-3377

N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea

1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea

N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea

1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea

[3H]-Fenobam

N-3-chlorophenyl-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea