WAY 629 hydrochloride

• 常用名: WAY 629 hydrochloride
• 英文名: WAY 629 hydrochloride
• CAS号: 57756-44-2
• 分子量: 262.778
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₉ClN₂
• 熔点: N/A
• 闪点: N/A

WAY 629 hydrochloride用途

WAY 629盐酸盐是一种强效选择性5-HT2C激动剂,5-HT2C和5-HT2A的EC50分别为426、260000 nM。WAY 629盐酸盐降低喂养行为[1][2]。

WAY 629 hydrochloride名称

• 英文名: WAY 629 hydrochloride

WAY 629 hydrochloride生物活性

• 描述: WAY 629盐酸盐是一种强效选择性5-HT2C激动剂,5-HT2C和5-HT2A的EC50分别为426、260000 nM。WAY 629盐酸盐降低喂养行为[1][2]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  5-HT2C Receptor:426 nM (EC50)

  5-HT2A Receptor:260000 nM (EC50)

• 体内研究: WAY 629盐酸盐(30 mg/kg；i.p.)降低大鼠的进食行为[1]。 WAY 629盐酸盐(30 mg/kg；i.p.)降低小鼠大脑中 NPY mRNA的表达[2]。 动物模型：WT小鼠[2]剂量：21 mg/kg给药：I.p.结果：NPY mRNA表达降低。
• 参考文献:

  [1]. Sabb AL, et al. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7.

  [2]. Aoki M, et al. Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair. Eur J Neurosci. 2016 May;43(9):1219-28.

WAY 629 hydrochloride物理化学性质

• 分子式: C₁₅H₁₉ClN₂
• 分子量: 262.778
• 精确质量: 262.123688
• InChIKey: PZXUJERSOFOWES-UHFFFAOYSA-N
• SMILES: Cl.c1cc2c3c(c1)c1c(n3CCNC2)CCCC1

WAY 629 hydrochloride靶点实验

查看更多实验

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

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WAY 629 hydrochloride英文别名

• MFCD06798323
• [1,4]Diazepino[6,7,1-jk]carbazole, 1,2,3,4,8,9,10,11-octahydro-, hydrochloride (1:1)
• 1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride (1:1)
• WAY 629 hydrochloride