卡前列素氨基丁三醇

更新时间：2025-08-25 22:38:58

卡前列素氨基丁三醇结构式	常用名	卡前列素氨基丁三醇	英文名	Carboprost tromethamine
	CAS号	58551-69-2	分子量	489.643
	密度	1.153g/cm3	沸点	536.6ºC at 760 mmHg
	分子式	C₂₅H₄₇NO₈	熔点	N/A
	MSDS	N/A	闪点	292.4ºC

卡前列素氨基丁三醇用途

Carboprost tromethamine 是前列腺素 F2α (prostaglandin F2α) 的 15 甲基类似物。Carboprost tromethamine 能有效促进子宫规律性收缩,显著减少产后出血量。

中文名	卡前列素氨基丁三醇
英文名	carboprost tromethamine
中文别名	(Z)-7-[(3R,5S)-3,5-二羟基-2-[(E,3S)-3-羟基-3-甲基辛-1-烯基]环戊基]庚-5-烯酸氨基丁三醇 \| 卡前列腺氨丁三醇
英文别名	更多

描述	Carboprost tromethamine 是前列腺素 F2α (prostaglandin F2α) 的 15 甲基类似物。Carboprost tromethamine 能有效促进子宫规律性收缩,显著减少产后出血量。
相关类别	研究领域 >> 内分泌信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
体内研究	卡前列素氨丁三醇对预防剖宫产产后出血有显著作用,对改善高凝状态、维持血流动力学稳定有显著作用。卡前列素氨丁三醇治疗因子宫收缩乏力而持续出血的成功率为84-96%。
参考文献	[1]. Ling Z, et al. Effect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section. Pak J Pharm Sci. 2018 Sep;31(5(Special)):2257-2262. [2]. Bai J, et al. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery. Exp Ther Med. 2014 Jan;7(1):46-50. Epub 2013 Nov 1.

密度	1.153g/cm3
沸点	536.6ºC at 760 mmHg
分子式	C₂₅H₄₇NO₈
分子量	489.643
闪点	292.4ºC
精确质量	489.330170
PSA	184.70000
LogP	1.79410
InChIKey	UMMADZJLZAPZAW-QTBVFXFVSA-N
SMILES	CCCCCC(C)(O)C=CC1C(O)CC(O)C1CC=CCCCC(=O)O.NC(CO)(CO)CO
储存条件	2-8°C，密闭，干燥
水溶解性	Soluble in water.

卡前列素氨基丁三醇毒性英文版

危险品运输编码	NONH for all modes of transport

[The use of prostaglandin F2alpha (Prostin 15M) for terminationof second trimester pregnancy].

Akush. Ginekol. (Sofiia.) 52(2) , 53-5, (2013)

The authors describe a case of terminating a second trimester pregnancy in 21 gestational weeks with use of Prostin 15 M. The patient come to the clinic in 21 gestational week with spontaneous rupture...

[Application of Pfizer drugs in the obstetrics and gynecology practice].

Akush. Ginekol. (Sofiia.) 48 Suppl 1 , 41-4, (2009)

[Some possibilities for application of Pfizer medicines--Prostin 15m, Prostin E2, Prepidil gel, Dostinex, Synarel--in the obstetrician practice].

Akush. Ginekol. (Sofiia.) 46 Suppl 2 , 57-60, (2007)

The authors make a clinical and pharmacological overview of the possibilities of application in the obstetrician practice of part of the medicines of the company Pfiser. Some of these medicines have n...

实验名称：Liver toxicity in human assessed as induction of drug-induced liver injury by measuri...
来源：ChEMBL
靶标：Homo sapiens
External Id：CHEMBL4029349

实验名称：Liver toxicity in human assessed as induction of drug-induced liver injury by measuri...
来源：ChEMBL
靶标：Homo sapiens
External Id：CHEMBL4029350

共2条，当前第1页，共1页

(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((E)-(3S)-3-hydroxy-3-methyl-1-octenyl)cyclopentyl)-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

(5Z,9α,11α,13E,15S)-9,11,15-Trihydroxy-15-methylprosta-5,13-dien-1-oic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)

(15S)-15-Methylprostaglandin F2a Tromethamine

(5Z,9α,11α,13E,15S)-9,11,15-Trihydroxy-15-methylprosta-5,13-dien-1-oic acid - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-3-methyloct-1-en-1-yl]cyclopentyl}hept-5-ensäure--2-amino-2-(hydroxymethyl)propan-1,3-diol(1:1)

Hemabate

Prostin/15M

acide (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-3-méthyloct-1-én-1-yl]cyclopentyl}hept-5-énoïque - 2-amino-2-(hydroxyméthyl)propane-1,3-diol (1:1)

Carboprost tromethamine salt

15(S)15-Methyl pgf2a Tromethamine Salt

Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9α,11α,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

(5Z,9a,11a,13E,15S)-9,11,15-Trihydroxy-15-methylprosta-5,13-dien-1-oic Acid compd. with 2-Amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

Carboprost trometamol

Carboprost tromethamine

U 32921E

(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-3-methyloct-1-en-1-yl]cyclopentyl}hept-5-enoic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)