非昔硝唑

• 常用名: 非昔硝唑
• 英文名: Fexinidazole
• CAS号: 59729-37-2
• 分子量: 279.315
• 密度: 1.3±0.1 g/cm3
• 沸点: 511.3±40.0 °C at 760 mmHg
• 分子式: C₁₂H₁₃N₃O₃S
• 熔点: N/A
• 闪点: 263.0±27.3 °C

非昔硝唑用途

Fexinidazole 是一种5-硝基咪唑药物, 可治疗寄生虫布氏锥虫引起感染的人类昏睡病。

非昔硝唑名称

• 中文名: 非昔硝唑
• 英文名: 1-methyl-2-[(4-methylsulfanylphenoxy)methyl]-5-nitroimidazole

非昔硝唑生物活性

• 描述: Fexinidazole 是一种5-硝基咪唑药物, 可治疗寄生虫布氏锥虫引起感染的人类昏睡病。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染
• 参考文献:

  [1]. Kaiser M, et al. Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness. Antimicrob Agents Chemother. 2011 Dec;55(12):5602-8.

非昔硝唑物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 511.3±40.0 °C at 760 mmHg
• 分子式: C₁₂H₁₃N₃O₃S
• 分子量: 279.315
• 闪点: 263.0±27.3 °C
• 精确质量: 279.067749
• PSA: 98.17000
• LogP: 2.28
• InChIKey: MIWWSGDADVMLTG-UHFFFAOYSA-N
• SMILES: CSc1ccc(OCc2ncc([N+](=O)[O-])n2C)cc1
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.629
• 储存条件: 2-8℃

非昔硝唑安全信息

• 海关编码: 2933290090

非昔硝唑海关

• 海关编码: 2933290090
• 中文概述: 2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

非昔硝唑靶点实验

查看更多实验

实验名称：Half life in mouse at 25 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL5533745

实验名称：Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense ... 来源：ChEMBL 靶标：Trypanosoma brucei rhodesiense External Id：CHEMBL4049097

实验名称：Tmax in mouse at 25 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL5533744

实验名称：Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4773766

实验名称：Antileishmanial activity against Leishmania donovani MHOM/IN/00/DEVI promastigotes as... 来源：ChEMBL 靶标：Leishmania donovani External Id：CHEMBL4773767

实验名称：Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incuba... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4345837

实验名称：Antitrypanosomal activity against Trypanosoma brucei brucei AnTat 1.9 trypomastigotes... 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL4345836

实验名称：Antileishmanial activity against Trypanosoma brucei brucei AnTat 1.9 measured after 7... 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL4771960

实验名称：Antileishmanial activity against Leishmania infantum MHOM/MA/67/ITMAP-263 axenic amas... 来源：ChEMBL 靶标：Leishmania infantum External Id：CHEMBL4345835

实验名称：Selectivity index, ratio of CC50 for human HepG2 cells to EC50 for Trypanosoma brucei... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4771961

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非昔硝唑英文别名

• 1-Methyl-2-{[4-(methylsulfanyl)phenoxy]methyl}-5-nitro-1H-imidazole
• 1-methyl-2-(4-methylthiophenyl-oxymethyl)-5-nitro-imidazole
• 1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole
• 1-methyl-2-(4-methylsulfanyl-phenoxymethyl)-5-nitro-1H-imidazole
• Fexinidazol
• Fexinidazole
• Fexinidazolum
• 1-Methyl-2-((p-(methylthio)phenoxy)methyl)-5-nitroimidazole
• HOE-239