光甘草素

• 常用名: 光甘草素
• 英文名: 2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol
• CAS号: 60008-03-9
• 分子量: 322.354
• 密度: 1.3±0.1 g/cm3
• 沸点: 536.3±50.0 °C at 760 mmHg
• 分子式: C₂₀H₁₈O₄
• 熔点: N/A
• 闪点: 278.2±30.1 °C

光甘草素用途

Glabrene 是一种来源于甘草根的异黄酮,具有雌激素样活性。Glabrene 是 tyrosinase 抑制剂,IC50 值为 3.5 μM。

光甘草素名称

• 中文名: 光甘草素
• 英文名: 8-(7-hydroxy-2H-chromen-3-yl)-2,2-dimethylchromen-5-ol

光甘草素生物活性

• 描述: Glabrene 是一种来源于甘草根的异黄酮,具有雌激素样活性。Glabrene 是 tyrosinase 抑制剂,IC50 值为 3.5 μM。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 代谢酶/蛋白酶 >> 酪氨酸酶
• 靶点实验:

  IC50: 3.5 μM (Tyrosinase)[2]

• 参考文献:

  [1]. Somjen D, et al. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues. J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):241-6.

  [2]. Nerya O, et al. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem. 2003 Feb 26;51(5):1201-7

光甘草素物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 536.3±50.0 °C at 760 mmHg
• 分子式: C₂₀H₁₈O₄
• 分子量: 322.354
• 闪点: 278.2±30.1 °C
• 精确质量: 322.120514
• PSA: 58.92000
• LogP: 6.72
• InChIKey: NGGYSPUAKQMTNP-UHFFFAOYSA-N
• SMILES: CC1(C)C=Cc2c(O)ccc(C3=Cc4ccc(O)cc4OC3)c2O1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.647
• 储存条件: 2-8℃，干燥，密闭

光甘草素安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2905399090

光甘草素海关

• 海关编码: 2905399090
• 中文概述: 2905399090 其他二元醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 包装
• 监管条件: A.入境货物通关单 B.出境货物通关单
• 检验检疫: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
• Summary: 2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

光甘草素靶点实验

查看更多实验

实验名称：Antifungal activity against Candida albicans ATCC 10231 at 100 mcg/ml by agar-dilutio... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL1025040

实验名称：Antibacterial activity against Mycobacterium smegmatis ATCC 607 by agar-dilution stre... 来源：ChEMBL 靶标：Mycolicibacterium smegmatis External Id：CHEMBL1025038

实验名称：Antiproliferative activity against human SW480 cells at 10 uM after 24 hrs by MTS ass... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL4053426

实验名称：Antibacterial activity against Salmonella gallinarum ATCC 9184 at 100 mcg/ml by agar-... 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Gallinarum External Id：CHEMBL1025035

实验名称：Antibacterial activity against Klebsiella pneumoniae ATCC 10031 at 100 mcg/ml by agar... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL1025036

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM after 6 h... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4053417

实验名称：Inhibition of recombinant human PTP1B using pNPP as substrate at 10 uM after 30 mins ... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL4053415

实验名称：Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate at 10 uM prei... 来源：ChEMBL 靶标：Tyrosinase External Id：CHEMBL4053412

实验名称：Antiproliferative activity against human A549 cells at 10 uM after 24 hrs by MTS assa... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4053424

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光甘草素英文别名

• 2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol
• Glabrene