2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol

Modify Date: 2024-01-12 10:10:39

2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol Structure
2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol structure
Common Name 2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol
CAS Number 60008-03-9 Molecular Weight 322.354
Density 1.3±0.1 g/cm3 Boiling Point 536.3±50.0 °C at 760 mmHg
Molecular Formula C20H18O4 Melting Point N/A
MSDS N/A Flash Point 278.2±30.1 °C

 Use of 2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol


Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC50 of 3.5 μM[1][2].

 Names

Name 8-(7-hydroxy-2H-chromen-3-yl)-2,2-dimethylchromen-5-ol
Synonym More Synonyms

  Biological Activity

Description Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC50 of 3.5 μM[1][2].
Related Catalog
Target

IC50: 3.5 μM (Tyrosinase)[2]

References

[1]. Somjen D, et al. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues. J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):241-6.

[2]. Nerya O, et al. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem. 2003 Feb 26;51(5):1201-7

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 536.3±50.0 °C at 760 mmHg
Molecular Formula C20H18O4
Molecular Weight 322.354
Flash Point 278.2±30.1 °C
Exact Mass 322.120514
PSA 58.92000
LogP 6.72
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.647

 Safety Information

Hazard Codes Xi
HS Code 2905399090

 Customs

HS Code 2905399090
Summary 2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

 Synonyms

2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol
Glabrene
[3,8'-Bi-2H-1-benzopyran]-5',7-diol, 2',2'-dimethyl-