10-Formyl-5,8-dideazafolic acid

• 常用名: 10-Formyl-5,8-dideazafolic acid
• 英文名: 10-Formyl-5,8-dideazafolic acid
• CAS号: 61038-31-1
• 分子量: 467.43100
• 密度: 1.54g/cm3
• 沸点: N/A
• 分子式: C₂₂H₂₁N₅O₇
• 熔点: N/A
• 闪点: N/A

10-Formyl-5,8-dideazafolic acid用途

10-甲酰基-5,8-二脱氧叶酸是一种胸苷酸合成酶抑制剂[1]。

10-Formyl-5,8-dideazafolic acid名称

• 英文名: 10-formyl-5,8-dideazafolate

10-Formyl-5,8-dideazafolic acid生物活性

• 描述: 10-甲酰基-5,8-二脱氧叶酸是一种胸苷酸合成酶抑制剂[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 胸苷酸合成酶
  研究领域 >> 癌症
• 靶点实验:

  thymidylate synthase[1]

• 参考文献:

  [1]. Reddy MR, et, al. Calculation of solvation and binding free energy differences for folate-based inhibitors of the enzyme thymidylate synthase. J. Am. Chem. Soc. 1992, 114, 26, 10117-10122.

10-Formyl-5,8-dideazafolic acid物理化学性质

• 密度: 1.54g/cm3
• 分子式: C₂₂H₂₁N₅O₇
• 分子量: 467.43100
• 精确质量: 467.14400
• PSA: 196.04000
• LogP: 2.73640
• InChIKey: QHUBQNFYSLRYQG-KRWDZBQOSA-M
• SMILES: Nc1nc2ccc(CN(C=O)c3ccc(C(=O)NC(CCC(=O)[O-])C(=O)O)cc3)cc2c(=O)[nH]1
• 折射率: 1.699

10-Formyl-5,8-dideazafolic acid靶点实验

查看更多实验

实验名称：Inhibition of rat liver dihydrofolate reductase using dihydrofolate as substrate 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL3253412

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Glucose transporter External Id：CHEMBL3436044

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 1 External Id：CHEMBL3436042

实验名称：Inhibition of Streptococcus faecium dihydrofolate reductase using dihydrofolate as su... 来源：ChEMBL 靶标：Dihydrofolate reductase External Id：CHEMBL3253413

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Hexose transporter 1 External Id：CHEMBL3436043

实验名称：Antitumor activity against mouse L1210 cells allografted in mouse assessed as increas... 来源：ChEMBL 靶标：L1210 External Id：CHEMBL3253416

实验名称：Antitumor activity against mouse L1210 cells allografted in mouse assessed as increas... 来源：ChEMBL 靶标：L1210 External Id：CHEMBL3253415

实验名称：Antitumor activity against mouse L1210 cells allografted in mouse assessed as increas... 来源：ChEMBL 靶标：L1210 External Id：CHEMBL3253417

实验名称：Biochemical screen of P. falciparum CDPK1 来源：1187 靶标：Calcium-Dependent Protein Kinase 1 (CDPK1) External Id：PfalCDPK1

实验名称：Biochemical screen of P. falciparum PK7 来源：1187 靶标：Protein Kinase 7 (PK7) External Id：PfalPK7

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