环二GMP

• 常用名: 环二GMP
• 英文名: Cyclic-di-GMP
• CAS号: 61093-23-0
• 分子量: 690.41100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₄N₁₀O₁₄P₂
• 熔点: N/A
• 闪点: N/A

环二GMP用途

Cyclic-di-GMP 是 STING 的激动剂也是一个可以调节不同细菌物种的生物膜形成，运动性和毒力的第二信使。

环二GMP名称

• 中文名: 环二GMP
• 英文名: c-di-GMP

环二GMP生物活性

• 描述: Cyclic-di-GMP 是 STING 的激动剂也是一个可以调节不同细菌物种的生物膜形成,运动性和毒力的第二信使。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 刺
  研究领域 >> 癌症
• 靶点实验:

  STING[1]

• 参考文献:

  [1]. Nakamura T, et al. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J Control Release. 2015 Oct 28;216:149-57.

  [2]. Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8.

环二GMP物理化学性质

• 分子式: C₂₀H₂₄N₁₀O₁₄P₂
• 分子量: 690.41100
• 精确质量: 690.09500
• PSA: 371.22000
• InChIKey: PKFDLKSEZWEFGL-MHARETSRSA-N
• SMILES: Nc1nc2c(ncn2C2OC3COP(=O)(O)OC4C(COP(=O)(O)OC3C2O)OC(n2cnc3c(=O)[nH]c(N)nc32)C4O)c(=O)[nH]1
• 储存条件: 2-8℃

环二GMP靶点实验

查看更多实验

实验名称：Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T ... 来源：ChEMBL 靶标：Stimulator of interferon genes protein External Id：CHEMBL4338400

实验名称：Activation of recombinant human STING haplotype R232H mutant expressed in 293T cells ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4338399

实验名称：Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in ... 来源：ChEMBL 靶标：Stimulator of interferon genes protein External Id：CHEMBL4338398

实验名称：Activation of recombinant human wild-type STING expressed in 293T cells measured afte... 来源：ChEMBL 靶标：Stimulator of interferon genes protein External Id：CHEMBL4338397

实验名称：Activation of recombinant human wild-type STING expressed in 293T cells incubated for... 来源：ChEMBL 靶标：Stimulator of interferon genes protein External Id：CHEMBL4338396

实验名称：Binding affinity to recombinant human wild-type STING assessed as change in melting t... 来源：ChEMBL 靶标：Stimulator of interferon genes protein External Id：CHEMBL4338395

实验名称：Inhibition of Pseudomonas aeruginosa WspR using [32P]-GTP as substrate at 100 uM afte... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2401359

实验名称：Antibacterial activity against Staphylococcus aureus NBRC13276 assessed as bacterial ... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4688339

实验名称：Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in ... 来源：ChEMBL 靶标：Stimulator of interferon genes protein External Id：CHEMBL4338408

实验名称：Antibacterial activity against Pseudomonas aeruginosa NBRC13275 assessed as bacterial... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL4688338

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环二GMP英文别名

• Cyclic diguanylate
• cyclic di-GMP
• 3',5'-Cyclic diguanylic acid
• Cyclic-di-GMP