DC4

• 常用名: DC4
• 英文名: DC4
• CAS号: 615538-48-2
• 分子量: 718.12
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₂₉ClN₅O₇PS
• 熔点: N/A
• 闪点: N/A

DC4用途

DC4 是一种 ADC 毒性小分子,可用于合成抗体-药物偶联物 (ADC)。DC4 可用于靶向治疗癌症。

DC4名称

• 英文名: DC4

DC4生物活性

• 描述: DC4 是一种 ADC 毒性小分子,可用于合成抗体-药物偶联物 (ADC)。DC4 可用于靶向治疗癌症。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗体- 药物偶联物 >> ADC细胞毒素
• 体外研究: DC4可通过连接子SPP、SPDB和SMCC与人源化单克隆抗体huB4和huC242结合形成huB4-SPP-DC44、huC242-SPDB-DC4、huC242-SPP-DC4和huC242-SMCC-DC4[1]。
• 参考文献:

  [1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.

DC4物理化学性质

• 分子式: C₃₄H₂₉ClN₅O₇PS
• 分子量: 718.12
• InChIKey: PWGCKOQNKYABMN-HXUWFJFHSA-N
• SMILES: O=C(CCS)Nc1ccc2[nH]c(C(=O)Nc3ccc4[nH]c(C(=O)N5CC(CCl)c6c5cc(OP(=O)(O)O)c5ccccc65)cc4c3)cc2c1

DC4靶点实验

查看更多实验

实验名称：Stability of the compound in 5 % DMA assessed as cyclopropyl ring formation incubated... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162480

实验名称：Prodrug activation assessed as enzyme-mediated compound dephosphorylation in presence... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162481

实验名称：Solubility in water containing 5% DMA at 1.5 mg sonicated for 45 mins followed by cen... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162478

实验名称：Solubility in water containing 5% DMF at 1.5 mg sonicated for 45 mins followed by cen... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162479

实验名称：Prodrug activation assessed as enzyme-mediated compound dephosphorylation in presence... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162482

实验名称：Solubility in DMF at 1.5 mg sonicated for 45 mins followed by centrifugation for 45 m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162470

实验名称：Solubility in water containing 5% dioxane at 1.5 mg sonicated for 45 mins followed by... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162476

实验名称：Solubility in water containing 5% DMSO at 1.5 mg sonicated for 45 mins followed by ce... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162477

实验名称：Solubility in water containing 5% THF at 1.5 mg sonicated for 45 mins followed by cen... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162474

实验名称：Solubility in water containing 5% acetone at 1.5 mg sonicated for 45 mins followed by... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2162475

共33条，当前第1页，共4页

1

2

3

4