alpha-[[2-(4-氟苯氧基)-9-甲基-4-氧代-4H-吡啶并[1,2-a]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈

• 常用名: alpha-[[2-(4-氟苯氧基)-9-甲基-4-氧代-4H-吡啶并[1,2-a]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈
• 英文名: CCG-63808
• CAS号: 620113-73-7
• 分子量: 454.47600
• 密度: 1.37
• 沸点: 534.5ºC at 760 mmHg
• 分子式: C₂₅H₁₅FN₄O₂S
• 熔点: N/A
• 闪点: 277ºC

用途

CCG-63808 是可逆的G蛋白信号调节子(RGS)抑制剂。

名称

• 中文名: alpha-[[2-(4-氟苯氧基)-9-甲基-4-氧代-4H-吡啶并[1,2-a]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈
• 英文名: (E)-2-(1,3-benzothiazol-2-yl)-3-[2-(4-fluorophenoxy)-9-methyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile

生物活性

• 描述: CCG-63808 是可逆的G蛋白信号调节子(RGS)抑制剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> RGS蛋白质
  研究领域 >> 癌症
• 参考文献:

  [1]. Levi L. Blazer et al.Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins. Molecular Pharmacology September 2010 vol.78 no.3 524-533

物理化学性质

• 密度: 1.37
• 沸点: 534.5ºC at 760 mmHg
• 分子式: C₂₅H₁₅FN₄O₂S
• 分子量: 454.47600
• 闪点: 277ºC
• 精确质量: 454.09000
• PSA: 108.52000
• LogP: 5.60818
• InChIKey: IPZHFKHGSYRBNT-DTQAZKPQSA-N
• SMILES: Cc1cccn2c(=O)c(C=C(C#N)c3nc4ccccc4s3)c(Oc3ccc(F)cc3)nc12
• 折射率: 1.695
• 储存条件: 2-8℃

靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

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英文别名

• hms1804o11
• CCG-63808