1-去氨基-8-右旋精氨酸加压素

更新时间：2024-01-02 14:16:39

1-去氨基-8-右旋精氨酸加压素结构式	常用名	1-去氨基-8-右旋精氨酸加压素	英文名	Desmopressin Acetate
	CAS号	62288-83-9	分子量	1129.269
	密度	1.56 g/cm3	沸点	1667.7ºC at 760 mmHg
	分子式	C₄₈H₆₈N₁₄O₁₄S₂	熔点	170-172ºC
	MSDS	N/A	闪点	962.4ºC

1-去氨基-8-右旋精氨酸加压素用途

Desmopressin(DDAVP)醋酸盐是抗利尿激素精氨酸加压素类似物。

中文名	1-去氨基-8-右旋精氨酸加压素
英文名	desmopressin
中文别名	醋酸去氨加压素
英文别名	更多

描述	Desmopressin(DDAVP)醋酸盐是抗利尿激素精氨酸加压素类似物。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体研究领域 >> 代谢疾病
参考文献	[1]. Vande Walle J, Stockner M, Raes A, N?rgaard JP. Desmopressin 30 years in clinical use: a safety review. Curr Drug Saf. 2007 Sep;2(3):232-8. [2]. Franchini M, Zaffanello M, Lippi G. The use of desmopressin in mild hemophilia A. Blood Coagul Fibrinolysis. 2010 Oct;21(7):615-9. [3]. Sánchez-Luceros A, Meschengieser SS, Woods AI et al. Biological and clinical response to desmopressin (DDAVP) in a retrospective cohort study of children with low von Willebrand factor levels and bleeding history. Thromb Haemost. 2010 Nov;104(5):984-9. [4]. Alonso DF, Ripoll GV, Garona J et al. Metastasis: recent discoveries and novel perioperative treatment strategies with particular interest in the hemostatic compound desmopressin. Curr Pharm Biotechnol. 2011 Nov;12(11):1974-80. [5]. Tsukamoto I. Recent patenting activities in the discovery and development of vasopressin V2 receptor agonists. Expert Opin Ther Pat. 2012 Jun;22(6):579-86. [6]. Desmopressin

描述

Desmopressin(DDAVP)醋酸盐是抗利尿激素精氨酸加压素类似物。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体

研究领域 >> 代谢疾病

参考文献

[1]. Vande Walle J, Stockner M, Raes A, N?rgaard JP. Desmopressin 30 years in clinical use: a safety review. Curr Drug Saf. 2007 Sep;2(3):232-8.

[2]. Franchini M, Zaffanello M, Lippi G. The use of desmopressin in mild hemophilia A. Blood Coagul Fibrinolysis. 2010 Oct;21(7):615-9.

[3]. Sánchez-Luceros A, Meschengieser SS, Woods AI et al. Biological and clinical response to desmopressin (DDAVP) in a retrospective cohort study of children with low von Willebrand factor levels and bleeding history. Thromb Haemost. 2010 Nov;104(5):984-9.

[4]. Alonso DF, Ripoll GV, Garona J et al. Metastasis: recent discoveries and novel perioperative treatment strategies with particular interest in the hemostatic compound desmopressin. Curr Pharm Biotechnol. 2011 Nov;12(11):1974-80.

[5]. Tsukamoto I. Recent patenting activities in the discovery and development of vasopressin V2 receptor agonists. Expert Opin Ther Pat. 2012 Jun;22(6):579-86.

[6]. Desmopressin

密度	1.56 g/cm3
沸点	1667.7ºC at 760 mmHg
熔点	170-172ºC
分子式	C₄₈H₆₈N₁₄O₁₄S₂
分子量	1129.269
闪点	962.4ºC
精确质量	1128.448120
PSA	523.31000
LogP	1.61440
储存条件	-20?C Freezer

危害码 (欧洲)	Xn
安全声明 (欧洲)	S36

Glycinamide, 1-[[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-L-prolyl-L-arginyl-, acetate (1:1) (salt)

1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide acetate (salt)

1-{[(4R,7S,10S,13S,16S)-7-(2-Amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide acetate (1:1)

acide acétique - (2S)-1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoéthyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-N-{(1S)-1-[(2-amino-2-oxoéthyl)carbamoyl]-4-carbamimidamidobutyl}pyrrolidine-2-carboxamide (1:1)

(2S)-1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-N-{(1S)-1-[(2-amino-2-oxoethyl)carbamoyl]-4-carbamimidamidobutyl}pyrrolidine-2-carboxamide acetate (salt)

(2S)-1-{[(4R,7S,10S,13S,16S)-7-(2-Amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-N-{(1S)-1-[(2-amino-2-oxoethyl)carbamoyl]-4-carbamimidamidobutyl}pyrrolidin-2-carboxamidacetat(salt)

Desmopressin (Acetate)