TBPB

• 常用名: TBPB
• 英文名: TBPB
• CAS号: 634616-95-8
• 分子量: 404.548
• 密度: 1.2±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₅H₃₂N₄O
• 熔点: N/A
• 闪点: N/A

TBPB用途

TBPB是M1 mAChR变构激动剂,EC50值为289nM,调节amyloid的加工和小鼠体内具有抗精神病药物等活性。

TBPB名称

• 中文名: TBPB
• 英文名: 1-[1'-(2-Methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benz imidazol-2-one

TBPB生物活性

• 描述: TBPB是M1 mAChR变构激动剂,EC50值为289nM,调节amyloid的加工和小鼠体内具有抗精神病药物等活性。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Jones CK, et al. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J Neurosci. 2008 Oct 8;28(41):10422-33.

  [2]. Miller NR, et al. Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5443-7.

TBPB物理化学性质

• 密度: 1.2±0.1 g/cm3
• 分子式: C₂₅H₃₂N₄O
• 分子量: 404.548
• 精确质量: 404.257599
• PSA: 44.53000
• LogP: 4.96
• InChIKey: CWPKTBMRVATCBL-UHFFFAOYSA-N
• SMILES: Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1
• 折射率: 1.623
• 储存条件: 2-8℃

TBPB安全信息

• 危险品运输编码: NONH for all modes of transport

TBPB靶点实验

查看更多实验

实验名称：Agonist activity at muscarinic M3 receptor 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M3 External Id：CHEMBL983584

实验名称：Displacement of [3H]NMS from rat muscarinic M1 receptor expressed in CHO cells after ... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL2319076

实验名称：Agonist activity at muscarinic M2 receptor 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M2 External Id：CHEMBL983583

实验名称：Agonist activity at muscarinic M5 receptor 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M5 External Id：CHEMBL983586

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Agonist activity at muscarinic M4 receptor 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M4 External Id：CHEMBL983585

实验名称：Agonist activity at muscarinic M1 receptor relative to carbachol 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL983580

实验名称：Agonist activity at muscarinic M1 receptor 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL983579

实验名称：Inhibition of dopamine D2 receptor 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL983581

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

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TBPB英文别名

• 2-Pyrrolo-1,3,2-dioxa-phospholan
• 1-[1'-(2-Methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one
• 2-pyrrol-1-yl-1,3,2-dioxaphospholan
• TBPB