亚胺培南

• 常用名: 亚胺培南
• 英文名: Imipenem
• CAS号: 64221-86-9
• 分子量: 299.346
• 密度: 1.6±0.1 g/cm3
• 沸点: 530.2±60.0 °C at 760 mmHg
• 分子式: C₁₂H₁₉N₃O₅S
• 熔点: 106-111ºC
• 闪点: 274.5±32.9 °C

亚胺培南用途

亚胺培南(N-甲酰胺基噻霉素,MK0787)是噻霉霉素的稳定结晶衍生物,是一种抗生素,对广泛的革兰氏阳性菌和革兰氏阴性需氧菌和厌氧菌具有优异的活性。亚胺培南(N-甲酰噻霉素,MK0787)可用于碳青霉烯不敏感和铜绿假单胞菌生物膜感染[1][2][3]。

亚胺培南名称

• 中文名: 亚胺培南
• 英文名: imipenem
• 中文别名: 6-(1-羟基乙基)-3-[[2-[(亚氨基甲基)氨基]乙基]硫]-7-氧代-1-氮杂双环[3.2.0]庚-2-烯-2-甲酸 | 亚安培南 | (5R,6S)-6-[(1R)-1-羟乙基]-3-[[2-[(亚氨基甲基)氨基]乙基]硫代]-7-氧代-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸单水合物

亚胺培南生物活性

• 描述: 亚胺培南(N-甲酰胺基噻霉素,MK0787)是噻霉霉素的稳定结晶衍生物,是一种抗生素,对广泛的革兰氏阳性菌和革兰氏阴性需氧菌和厌氧菌具有优异的活性。亚胺培南(N-甲酰噻霉素,MK0787)可用于碳青霉烯不敏感和铜绿假单胞菌生物膜感染[1][2][3]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Johann Motsch, et al. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections. Clin Infect Dis. 2020 Apr 15;70(9):1799-1808.

  [2]. F P Tally, et al. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642-4.

  [3]. Wang Hengzhuang, et al. In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother. 2012 May;56(5):2683-90.

亚胺培南物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 530.2±60.0 °C at 760 mmHg
• 熔点: 106-111ºC
• 分子式: C₁₂H₁₉N₃O₅S
• 分子量: 299.346
• 闪点: 274.5±32.9 °C
• 精确质量: 299.093964
• PSA: 148.25000
• LogP: -2.78
• InChIKey: ZSKVGTPCRGIANV-ZXFLCMHBSA-N
• SMILES: CC(O)C1C(=O)N2C(C(=O)O)=C(SCCN=CN)CC12
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.721

亚胺培南毒性和生态

亚胺培南安全信息

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-27-36/37/39
• 海关编码: 29419000

亚胺培南海关

• 海关编码: 29419000

亚胺培南靶点实验

查看更多实验

实验名称：Antibacterial activity against Pseudomonas aeruginosa P334 assessed as mutant prevent... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1267703

实验名称：Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL3858107

实验名称：Antibacterial activity against Pseudomonas aeruginosa P337 assessed as mutant prevent... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1267704

实验名称：Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL3858108

实验名称：Antibacterial activity against Pseudomonas aeruginosa P338 assessed as mutant prevent... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1267705

实验名称：Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL3858109

实验名称：Antibacterial activity against Pseudomonas aeruginosa P328 assessed as mutant prevent... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1267706

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL3858110

实验名称：Antibacterial activity against Pseudomonas aeruginosa P352 assessed as mutant prevent... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1267707

共5869条，当前第1页，共587页

1

2

3

4

5

亚胺培南英文别名

• N-Formimidoylthienamycin
• LMipeneM
• imipenam
• (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• EINECS 264-734-5
• (5R,6S)-6-(1-hydroxyethyl)-3-({2-[(iminiomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• (5R,6S)-3-((2-(Formimidoylamino)ethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
• Tienamycin
• imipemide
• N-Formimidoylthiena
• (5R,6S)-6-((R)-1-Hydroxyethyl)-3-(2-(iminomethylamino)ethylthio)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carbonsaeure
• Imipenem (JP14)
• Imipenen
• mk-787
• Imipenem
• MFCD00864955