L 152804

• 常用名: L 152804
• 英文名: L-152,804
• CAS号: 6508-43-6
• 分子量: 366.45000
• 密度: 1.23g/cm3
• 沸点: 506.7ºC at 760 mmHg
• 分子式: C₂₃H₂₆O₄
• 熔点: N/A
• 闪点: 173ºC
• 符号: GHS06, GHS09
• 信号词: Danger

L 152804用途

L 152804 是口服有效的、选择性的神经肽 Y Y5受体 (NPY5-R) 的拮抗剂,其对hY5 的Ki 值为 26 nM。L 152804通过调节食物摄入和能量消耗,使饮食引起的肥胖小鼠体重减轻。

L 152804名称

• 英文名: L-152,804,5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione

L 152804生物活性

• 描述: L 152804 是口服有效的、选择性的神经肽 Y Y5受体 (NPY5-R) 的拮抗剂,其对hY5 的Ki 值为 26 nM。L 152804通过调节食物摄入和能量消耗,使饮食引起的肥胖小鼠体重减轻。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体
• 靶点实验:

  Ki: 26 nM (NPY5-R)[1].

• 体外研究: L 152804显示的选择性高于hy1、hy2和hy4受体的300倍[1]。
• 参考文献:

  [1]. Kanatani A, et al. L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73.

  [2]. Mashiko S, et al. A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14.

L 152804物理化学性质

• 密度: 1.23g/cm3
• 沸点: 506.7ºC at 760 mmHg
• 分子式: C₂₃H₂₆O₄
• 分子量: 366.45000
• 闪点: 173ºC
• 精确质量: 366.18300
• PSA: 60.44000
• LogP: 4.38020
• InChIKey: XQDXIHYKAGHZRX-UHFFFAOYSA-N
• SMILES: CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3ccccc32)C(=O)C1
• 折射率: 1.603
• 储存条件: 2-8℃

L 152804安全信息

• 符号: GHS06, GHS09
• 信号词: Danger
• 危害声明: H301-H410
• 警示性声明: P273-P301 + P310-P501
• 危险品运输编码: UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

L 152804靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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L 152804英文别名

• 9-dimedonyl-3,3-dimethyl-1,2,3,4-tetrahydro-9H-xanthen-1-one
• 9-<4,4-Dimethyl-2,6-dioxo-cyclohexyl>-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-xanthen
• L-152,804