蓟黄素

• 常用名: 蓟黄素
• 英文名: Scrophulein
• CAS号: 6601-62-3
• 分子量: 314.289
• 密度: 1.4±0.1 g/cm3
• 沸点: 563.6±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄O₆
• 熔点: N/A
• 闪点: 211.5±23.6 °C
• 符号: GHS06, GHS09
• 信号词: Danger

蓟黄素用途

Cirsimaritin可以较弱的靶向结合 GABAA 受体上的苯二氮平位点,并拥有抗抑郁、抗焦虑、抗接种等活性。

蓟黄素名称

• 中文名: 蓟黄素
• 英文名: cirsimaritin

蓟黄素生物活性

• 描述: Cirsimaritin可以较弱的靶向结合 GABAA 受体上的苯二氮平位点,并拥有抗抑郁、抗焦虑、抗接种等活性。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  信号通路 >> 神经信号通路 >> GABA受体
  研究领域 >> 神经疾病
  天然产物 >> 其他
• 体内研究: Cirsimaritin显着降低小鼠的焦虑。氟马西尼(2.5 mg/kg)与salvigenin,rosmanol和cirsimaritin(10 mg/kg)联合给药可降低Cirsimaritin,表明高亲和性苯二氮卓结合位点不参与这些化合物诱导的抗焦虑活性[ 1]。
• 参考文献:

  [1]. Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. J Pharm Pharm Sci. 2015;18(4):448-59.

蓟黄素物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 563.6±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄O₆
• 分子量: 314.289
• 闪点: 211.5±23.6 °C
• 精确质量: 314.079041
• PSA: 89.13000
• LogP: 1.97
• InChIKey: ZIIAJIWLQUVGHB-UHFFFAOYSA-N
• SMILES: COc1cc2oc(-c3ccc(O)cc3)cc(=O)c2c(O)c1OC
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.646
• 储存条件: ?20°C

蓟黄素安全信息

• 符号: GHS06, GHS09
• 信号词: Danger
• 危害声明: H301-H410
• 警示性声明: P273-P301 + P310-P501
• 危害码 (欧洲): T,N
• 风险声明 (欧洲): 25-50
• 安全声明 (欧洲): 45-61
• 危险品运输编码: UN 2811 6.1 / PGIII
• 海关编码: 2914509090

蓟黄素海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

蓟黄素靶点实验

查看更多实验

实验名称：Antibacterial activity against Enterococcus faecalis MB76 after 24 hrs by microdiluti... 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL4611983

实验名称：Antibacterial activity against Vancomycin resistant Enterococcus faecalis MB51 after ... 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL4611982

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Antibacterial activity against Enterococcus faecium MB3 after 24 hrs by microdilution... 来源：ChEMBL 靶标：Enterococcus faecium External Id：CHEMBL4611985

实验名称：Antibacterial activity against Enterococcus faecium MB2 after 24 hrs by microdilution... 来源：ChEMBL 靶标：Enterococcus faecium External Id：CHEMBL4611984

实验名称：Antioxidant activity assessed as trolox equivalents of AAPH radical scavenging activi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4054196

实验名称：Antibacterial activity against Enterococcus avium MB119 after 24 hrs by microdilution... 来源：ChEMBL 靶标：Enterococcus avium External Id：CHEMBL4611987

实验名称：Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate afte... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL4054197

实验名称：Antibacterial activity against Enterococcus faecium MB152 after 24 hrs by microdiluti... 来源：ChEMBL 靶标：Enterococcus faecium External Id：CHEMBL4611986

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

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蓟黄素英文别名

• 5,4'-dihydroxy-6,7-dimethoxyflavone
• 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxychromen-4-one
• 6,7-Dimethoxyscutellarein
• Circimaritin
• 7-Methylcapillarisin
• 5-Hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-chromen-4-one
• cirsimartin
• 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-chromen-4-one
• Scrophulein
• 4H-1-Benzopyran-4-one,5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy
• Skrofulein
• 4',5-Dihydroxy-6,7-dimethoxyflavone
• cirsimaritin