硫氧洛尔

• 常用名: 硫氧洛尔
• 英文名: Sulfinalol
• CAS号: 66264-77-5
• 分子量: 377.50
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₇NO₄S
• 熔点: N/A
• 闪点: N/A

硫氧洛尔用途

磺醛醇是一种口服活性β-肾上腺素受体拮抗剂,具有直接的血管扩张活性[1]。

硫氧洛尔名称

• 中文名: 硫氧洛尔
• 英文名: 4-[1-hydroxy-2-[4-(4-methoxyphenyl)butan-2-ylamino]ethyl]-2-methylsulfinylphenol

硫氧洛尔生物活性

• 描述: 磺醛醇是一种口服活性β-肾上腺素受体拮抗剂,具有直接的血管扩张活性[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
• 靶点实验:

  β-adrenoceptor

• 体内研究: 磺醛醇具有直接的血管扩张活性和抗高血压活性[1]。动物模型：体重8.7-21.2 kg的杂种狗用戊巴比妥(30-35 mg/kg,静脉注射,然后连续输注4 mg/kg/h)[1]剂量：0-100µg给药：动脉内注射结果：麻醉狗失去交感神经的后肢血流量增加。动物模型：雄性自发性高血压大鼠(SHR)[1]剂量：2.5 mg/kg给药：口服结果：清醒自发性高血压大鼠血压降低。
• 参考文献:

  [1]. E J Sybertz, et al. Studies on the mechanism of the acute antihypertensive and vasodilator actions of several beta-adrenoceptor antagonists. J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):749-58.

硫氧洛尔物理化学性质

• 分子式: C₂₀H₂₇NO₄S
• 分子量: 377.50
• 精确质量: 377.16600
• PSA: 98.00000
• LogP: 4.03910
• InChIKey: PAQZZCOZHPGCFW-UHFFFAOYSA-N
• SMILES: COc1ccc(CCC(C)NCC(O)c2ccc(O)c(S(C)=O)c2)cc1

硫氧洛尔靶点实验

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实验名称：Binding affinity towards human ADRA2A in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL5291736

实验名称：Binding affinity towards human GABRA1 in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL5291799

实验名称：Binding affinity towards human PGR in an in vitro assay with cellular components meas... 来源：ChEMBL 靶标：Progesterone receptor External Id：CHEMBL5291863

实验名称：Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluor... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291731

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with ... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5291728

实验名称：Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay m... 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A External Id：CHEMBL5291856

实验名称：Binding affinity towards human OPRM1 in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL5291855

实验名称：Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291730

实验名称：Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL5291794

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硫氧洛尔英文别名

• SULFINALOL
• Sulfinalolum