二氢愈创木脂酸

• 常用名: 二氢愈创木脂酸
• 英文名: Dihydroguaiaretic acid
• CAS号: 66322-34-7
• 分子量: 330.418
• 密度: 1.1±0.1 g/cm3
• 沸点: 488.3±40.0 °C at 760 mmHg
• 分子式: C₂₀H₂₆O₄
• 熔点: N/A
• 闪点: 249.1±27.3 °C

二氢愈创木脂酸用途

Dihydroguaiaretic acid,从五味子的果实中分离,具有抗癌活性。

二氢愈创木脂酸名称

• 中文名: 二氢愈创木脂酸
• 英文名: 4-[(2R,3S)-4-(4-Hydroxy-3-methoxyphenyl)-2,3-dimethylbutyl]-2-met hoxyphenol

二氢愈创木脂酸生物活性

• 描述: Dihydroguaiaretic acid,从五味子的果实中分离,具有抗癌活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: 二氢愈创木酸对人卵巢癌细胞和A2780人子宫内膜癌细胞石川具有抑制作用,IC50值分别为27.17μM和45.46μM[1]。
• 参考文献:

  [1]. Arch Pharm Res. 2017 Apr;40(4):500-508. doi: 10.1007/s12272-017-0902-5. Epub 2017 Feb 22.

二氢愈创木脂酸物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 488.3±40.0 °C at 760 mmHg
• 分子式: C₂₀H₂₆O₄
• 分子量: 330.418
• 闪点: 249.1±27.3 °C
• 精确质量: 330.183105
• PSA: 58.92000
• LogP: 4.33
• InChIKey: ADFOLUXMYYCTRR-OKILXGFUSA-N
• SMILES: COc1cc(CC(C)C(C)Cc2ccc(O)c(OC)c2)ccc1O
• 外观性状: 粉末
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.564
• 储存条件: 2-8℃，干燥，密闭

二氢愈创木脂酸安全信息

• 危害码 (欧洲): Xi

二氢愈创木脂酸靶点实验

查看更多实验

实验名称：Cytotoxicity against African green monkey Vero cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：Vero External Id：CHEMBL4046884

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Selectivity index, ratio of CC50 for human C8166 cells to EC50 for HIV1 3B 来源：ChEMBL 靶标：N/A External Id：CHEMBL1058084

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cytotoxicity against human C8166 cells by MTT assay 来源：ChEMBL 靶标：C8166 External Id：CHEMBL1058082

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antiviral activity against HIV1 3B in human C8166 cells assessed as inhibition of vir... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL1058083

实验名称：Selectivity index, ratio of IC50 for cytotoxicity against African green monkey Vero c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4046891

实验名称：Antimycobacterial activity against isoniazid/rifampicin/ethambutol-resistant Mycobact... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4046889

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二氢愈创木脂酸英文别名

• Tetrahydrothebaine
• Dihydroguaiaretic acid
• 4,4'-dihydroxy-3,3'-dimethoxylignan
• 4,5alpha-Epoxy-3,6-dimethoxy-17-methylmorphinan
• 4-[(2R,3S)-4-(4-Hydroxy-3-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol
• meso-4,4'-dihydroxy-3,3'-dimethoxylignane
• meso-dihydroguaiaretic acid