3-甲基-6-(3-[三氟甲基]苯基)-1,2,4-噻唑并-(4,3-b)吡嗪

• 常用名: 3-甲基-6-(3-[三氟甲基]苯基)-1,2,4-噻唑并-(4,3-b)吡嗪
• 英文名: CL 218872
• CAS号: 66548-69-4
• 分子量: 278.23300
• 密度: 1.43g/cm3
• 沸点: N/A
• 分子式: C₁₃H₉F₃N₄
• 熔点: N/A
• 闪点: N/A

用途

CL 218872是一种选择性的口服活性苯二氮卓,其α1亚基含有GABAAR受体,Ki为130 nM。CL 218872在体内发挥抗焦虑和抗惊厥作用【1】。

名称

• 中文名: 3-甲基-6-(3-[三氟甲基]苯基)-1,2,4-噻唑并-(4,3-b)吡嗪
• 英文名: 3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine

生物活性

• 描述: CL 218872是一种选择性的口服活性苯二氮卓,其α1亚基含有GABAAR受体,Ki为130 nM。CL 218872在体内发挥抗焦虑和抗惊厥作用【1】。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 参考文献:

  [1]. Squires RF, et al. Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol Biochem Behav. 1979 May;10(5):825-30.

物理化学性质

• 密度: 1.43g/cm3
• 分子式: C₁₃H₉F₃N₄
• 分子量: 278.23300
• 精确质量: 278.07800
• PSA: 43.08000
• LogP: 3.11850
• InChIKey: GUOQUXNJZHGPQF-UHFFFAOYSA-N
• SMILES: Cc1nnc2ccc(-c3cccc(C(F)(F)F)c3)nn12
• 折射率: 1.615
• 储存条件: -20°C

靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：In vitro binding affinity against benzodiazepine receptor using [3H]diazepam as radio... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL653129

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

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英文别名

• CL 218,872
• Tocris-1709