5-甲氧基-3-(1,2,3,6-四氢吡啶-4-基)-1H-吲哚

更新时间：2025-08-25 03:42:20

5-甲氧基-3-(1,2,3,6-四氢吡啶-4-基)-1H-吲哚结构式	常用名	5-甲氧基-3-(1,2,3,6-四氢吡啶-4-基)-1H-吲哚	英文名	RU 24969
	CAS号	66611-26-5	分子量	228.29000
	密度	N/A	沸点	N/A
	分子式	C₁₄H₁₆N₂O	熔点	N/A
	MSDS	N/A	闪点	N/A

用途

RU 24969是5-HT1A和5-HT1B受体的选择性激动剂。

中文名	5-甲氧基-3-(1,2,3,6-四氢-4-吡啶)-1H-吲哚
英文名	5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
英文别名	更多

描述	RU 24969是5-HT1A和5-HT1B受体的选择性激动剂。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体信号通路 >> 神经信号通路 >> 5-HT受体研究领域 >> 神经疾病
参考文献	[1]. Doods HN, et al. Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity. Eur J Pharmacol. 1985 Jun 19;112(3):363-70. [2]. Green AR, et al. The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatment with antidepressants. Neuropharmacology. 1984 Jun;23(6):655-61. [3]. Aronsen D, et al. RU 24969-produced adipsia and hyperlocomotion: Differential role of 5HT1A and 5HT1B receptor mechanisms. Pharmacol Biochem Behav. 2014 May 15;124C:1-4. [4]. Cheetham SC, et al. Evidence that RU 24969-induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5-HT1B receptor. Br J Pharmacol. 1993 Dec;110(4):1621-9.

描述

RU 24969是5-HT1A和5-HT1B受体的选择性激动剂。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 神经疾病

参考文献

[1]. Doods HN, et al. Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity. Eur J Pharmacol. 1985 Jun 19;112(3):363-70.

[2]. Green AR, et al. The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatment with antidepressants. Neuropharmacology. 1984 Jun;23(6):655-61.

[3]. Aronsen D, et al. RU 24969-produced adipsia and hyperlocomotion: Differential role of 5HT1A and 5HT1B receptor mechanisms. Pharmacol Biochem Behav. 2014 May 15;124C:1-4.

[4]. Cheetham SC, et al. Evidence that RU 24969-induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5-HT1B receptor. Br J Pharmacol. 1993 Dec;110(4):1621-9.

分子式	C₁₄H₁₆N₂O
分子量	228.29000
精确质量	228.12600
PSA	37.05000
LogP	2.88200
InChIKey	KRVMLPUDAOWOGN-UHFFFAOYSA-N
SMILES	COc1ccc2[nH]cc(C3=CCNCC3)c2c1
储存条件	2-8℃

海关编码	2933990090

5-甲氧基吲哚

1006-94-6

4-氧代哌啶酮盐酸盐

41979-39-9

~88%

5-甲氧基-3-(1,2,3,...

66611-26-5

文献：BIO-MEDISINSK INNOVASJON AS; COCKBAIN, Julian Patent: WO2007/7072 A1, 2007 ; Location in patent: Page/Page column 21-22 ; WO 2007/007072 A1

5-甲氧基吲哚

1006-94-6

4,4-哌啶二醇盐酸盐

40064-34-4

7-chloro-3-(1,2...

180160-69-4

5-甲氧基-3-(1,2,3,...

66611-26-5

文献：Eli Lilly and Company Patent: US5614523 A1, 1997 ; US 5614523 A

5-甲氧基吲哚

1006-94-6

4,4-哌啶二醇盐酸盐

40064-34-4

5-甲氧基-3-(1,2,3,...

66611-26-5

文献：Eli Lilly and Company Patent: US5846982 A1, 1998 ; US 5846982 A

4-哌啶酮

41661-47-6

5-甲氧基吲哚

1006-94-6

5-甲氧基-3-(1,2,3,...

66611-26-5

文献：Mattsson, Cecilia; Sonesson, Clas; Sandahl, Anna; Greiner, Hartmut E.; Gassen, Michael; Plaschke, Joerg; Leibrock, Joachim; Boettcher, Henning Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4230 - 4234

上游产品 4
CAS号1006-94-6 5-甲氧基吲哚 CAS号41979-39-9 4-氧代哌啶酮盐酸盐 CAS号40064-34-4 4,4-哌啶二醇盐酸盐 CAS号41661-47-6 4-哌啶酮
下游产品 1
CAS号52157-82-1 5-甲氧基-3-哌啶-4-基-1H-吲哚

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%