Astressin 2B

更新时间：2024-01-27 21:11:47

Astressin 2B结构式	常用名	Astressin 2B	英文名	Astressin 2B
	CAS号	681260-70-8	分子量	4041.69000
	密度	N/A	沸点	N/A
	分子式	C₁₈₃H₃₀₇N₄₉O₅₃	熔点	N/A
	MSDS	中文版美版	闪点	N/A

Astressin 2B用途

Astressin 2B 是一种有效的选择性的促肾上腺皮质激素释放因子受体2 (corticotropin-releasing factor receptor 2 (CRF2)) 拮抗剂,对 CRF2 和 CRF1的 IC50 值分别为 1.3 和 > 500 nM。Astressin 2B 拮抗 CRF2 介导的胃排空抑制。

英文名	Astressin2B trifluoroacetate salt
英文别名	更多

描述	Astressin 2B 是一种有效的选择性的促肾上腺皮质激素释放因子受体2 (corticotropin-releasing factor receptor 2 (CRF2)) 拮抗剂,对 CRF2 和 CRF1的 IC50 值分别为 1.3 和 > 500 nM。Astressin 2B 拮抗 CRF2 介导的胃排空抑制。
相关类别	信号通路 >> 跨膜转运 >> CFTR 研究领域 >> 其他
参考文献	[1]. Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem. 2002;45(21):4737-4747. [2]. Hoare SR, et al. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides. 2005;26(3):457-470. [3]. Henry B, et al. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci. 2006;26(36):9142-9152.

描述

相关类别

信号通路 >> 跨膜转运 >> CFTR

研究领域 >> 其他

参考文献

[1]. Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem. 2002;45(21):4737-4747.

[2]. Hoare SR, et al. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides. 2005;26(3):457-470.

[3]. Henry B, et al. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci. 2006;26(36):9142-9152.

分子式	C₁₈₃H₃₀₇N₄₉O₅₃
分子量	4041.69000
精确质量	4039.28000
PSA	1686.63000
LogP	10.19370

安全声明 (欧洲)	22-24/25

Vasopressin potentiates corticotropin-releasing hormone-induced insulin release from mouse pancreatic beta-cells.

J. Endocrinol. 197(2) , 231-9, (2008)

Arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH) have both been implicated in modulating insulin secretion from pancreatic beta-cells. In the present study, we investigated the ins...

Astressin 2B