glycoprotein 3-α-L-fucosyltransferase

• 常用名: glycoprotein 3-α-L-fucosyltransferase
• 英文名: glycoprotein 3-α-L-fucosyltransferase
• CAS号: 68247-53-0
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: N/A
• 熔点: N/A
• 闪点: N/A

用途

需要Mn2+。该酶转移到N-连接的低聚糖结构(N-聚糖),通常对带有一个未取代的非还原末端GlcNAc残基的N-聚糖具有特异性。这种酶催化的反应类似于酶代码EC2.4.1.68,糖蛋白6-α-L-岩藻糖基转移酶,但将L-岩藻糖基从GDP-β-L-岩藻糖转移到形成α1,3-键而不是α1,6-键。这种酶的N-聚糖产物存在于植物、昆虫和一些其他无脊椎动物(如血吸虫、血吸虫、淋菌)中。 反应：GDP-β-L-fucose + N4-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-[α-L-fucosyl-(1→3)]-N-acetyl-β-D-glucosaminyl}asparagine

名称

• 英文名: glycoprotein 3-α-L-fucosyltransferase

生物活性

• 描述: 需要Mn2+。该酶转移到N-连接的低聚糖结构(N-聚糖),通常对带有一个未取代的非还原末端GlcNAc残基的N-聚糖具有特异性。这种酶催化的反应类似于酶代码EC2.4.1.68,糖蛋白6-α-L-岩藻糖基转移酶,但将L-岩藻糖基从GDP-β-L-岩藻糖转移到形成α1,3-键而不是α1,6-键。这种酶的N-聚糖产物存在于植物、昆虫和一些其他无脊椎动物(如血吸虫、血吸虫、淋菌)中。 反应：GDP-β-L-fucose + N4-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-[α-L-fucosyl-(1→3)]-N-acetyl-β-D-glucosaminyl}asparagine

物理化学性质

暂时没有任何物化性质资料

英文别名

• EC 2.4.1.214
• GDP-L-Fuc:N-acetyl-β-D-glucosaminide α1,3-fucosyltransferase
• GDP-L-Fuc:Asn-linked GlcNAc α1,3-fucosyltransferase
• GDP-fucose:β-N-acetylglucosamine (Fuc to (Fucα1→6GlcNAc)-Asn-peptide) α1→3-fucosyltransferase
• GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine) 3-α-L-fucosyl-transferase
• GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine) 3-α-L-fucosyl-transferase