戈米辛N

• 常用名: 戈米辛N
• 英文名: Gomisin N
• CAS号: 69176-52-9
• 分子量: 400.465
• 密度: 1.148±0.06 g/cm3
• 沸点: 545.0±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₈O₆
• 熔点: 104-108 ºC
• 闪点: 220.4±30.0 °C

戈米辛N用途

Gomisin N 是从Schisandra chinensis 中分离得到的,具有良好的镇静催眠作用。Gomisin N 有治疗过敏的潜力。Gomisin N 还是一种具有通过诱导癌细胞凋亡从而发挥抗肿瘤增值作用的候选药物。

戈米辛N名称

• 中文名: 戈米辛 N
• 英文名: Gomisin N

戈米辛N生物活性

• 描述: Gomisin N 是从Schisandra chinensis 中分离得到的,具有良好的镇静催眠作用。Gomisin N 有治疗过敏的潜力。Gomisin N 还是一种具有通过诱导癌细胞凋亡从而发挥抗肿瘤增值作用的候选药物。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Zhang C, et al. Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system. Fitoterapia. 2014 Jul;96:123-30.

  [2]. Chae HS, et al. Gomisin N has anti-allergic effect and inhibits inflammatory cytokine expression in mouse bone marrow-derived mast cells. Immunopharmacol Immunotoxicol. 2011 Dec;33(4):709-13.

  [3]. Yim SY, et al. Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma. Mol Med Rep. 2009 Sep-Oct;2(5):725-32.

戈米辛N物理化学性质

• 密度: 1.148±0.06 g/cm3
• 沸点: 545.0±50.0 °C at 760 mmHg
• 熔点: 104-108 ºC
• 分子式: C₂₃H₂₈O₆
• 分子量: 400.465
• 闪点: 220.4±30.0 °C
• 精确质量: 400.188599
• PSA: 55.38000
• LogP: 6.46
• 外观性状: 白色晶体或粉末
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.543
• 储存条件: 2-8°C
• 水溶解性: Insuluble (1.0E-3 g/L) (25 ºC)

戈米辛N靶点实验

查看更多实验

实验名称：Cell cycle arrest in human HL60/MDR cells assessed as accumulation at G1 phase at 25 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3372878

实验名称：Antiproliferative activity against human SNU638 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：SNU-638 External Id：CHEMBL928951

实验名称：Antiproliferative activity against human T47D cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：T47D External Id：CHEMBL928952

实验名称：Cell cycle arrest in human HL60/MDR cells assessed as accumulation at S phase at 25 u... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3372880

实验名称：Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulated hyd... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL977837

实验名称：Antiproliferative activity against human HCT15 cells after 72 hrs by SRB assay 来源：ChEMBL 靶标：HCT-15 External Id：CHEMBL928953

实验名称：Cell cycle arrest in human HL60/MDR cells assessed as accumulation at G2/M phase at 2... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3372879

实验名称：Antiproliferative activity against human K562 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：K562 External Id：CHEMBL928954

实验名称：Potentiation of doxorubicin-induced cell cycle arrest in human HL60/MDR cells assesse... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3372882

实验名称：Potentiation of doxorubicin-induced cell cycle arrest in human HL60/MDR cells assesse... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3372881

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戈米辛N英文别名

• 1beta,4betaH,10betaH-Guaia-5,11-diene
• 5,11-Guaiadiene
• 7-Isopropenyl-1,4-dimethyl-1,2,3,3a,4,5,6,7-octahydroazulene
• schisandrin B
• (-)-gomisin
• (3R,6R,7R,10R)-6,10-DIMETHYL-3-ISOPROPENYL-BICYCLO[5.3.0]DEC-1-ENE
• (-)-gomisin N
• 1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole
• [1R-(1alpha,3abeta,4alpha,7beta)]-1,2,3,3a,4,5,6,7-octahydro-7-isopropenyl-1,4-dimethylazulene