舒巴坦匹酯

• 常用名: 舒巴坦匹酯
• 英文名: Sulbactam pivoxil
• CAS号: 69388-79-0
• 分子量: 347.384
• 密度: 1.4±0.1 g/cm3
• 沸点: 537.5±50.0 °C at 760 mmHg
• 分子式: C₁₄H₂₁NO₇S
• 熔点: N/A
• 闪点: 278.9±30.1 °C

舒巴坦匹酯用途

是β-内酰胺酶抑制剂

舒巴坦匹酯名称

• 中文名: 舒巴坦匹酯
• 英文名: 2,2-dimethylpropanoyloxymethyl 3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• 中文别名: 3,3-二甲基-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-4,4-二氧化-2-羧酸 (2,2-二甲基-1-氧代丙氧)甲基酯 | 舒巴坦

舒巴坦匹酯生物活性

• 描述: 舒巴坦酯是舒巴坦的前药。舒巴坦钠是一种β-内酰胺酶抑制剂,在胃肠道的吸附性较差。舒巴坦匹沃酯比母体药物有更好的吸收,口服后可提供较高的血清水平[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Changov LS, et al. An efficient method for the synthesis of sulbactam pivoxil. Farmaco. 2000;55(2):134-135.

舒巴坦匹酯物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 537.5±50.0 °C at 760 mmHg
• 分子式: C₁₄H₂₁NO₇S
• 分子量: 347.384
• 闪点: 278.9±30.1 °C
• 精确质量: 347.103882
• PSA: 115.43000
• LogP: -0.02
• InChIKey: OHPVYKXTRACOSQ-ZJUUUORDSA-N
• SMILES: CC(C)(C)C(=O)OCOC(=O)C1N2C(=O)CC2S(=O)(=O)C1(C)C
• 外观性状: 固体
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.538
• 储存条件: 2-8°C，干燥

舒巴坦匹酯安全信息

• 危害码 (欧洲): Xn

舒巴坦匹酯靶点实验

查看更多实验

实验名称：Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303810

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Maximum Concentration of the compound. 来源：ChEMBL 靶标：N/A External Id：CHEMBL626212

实验名称：Ratio is calculated as AUC to AUC of Sulbactam pivoxil (control) 来源：ChEMBL 靶标：N/A External Id：CHEMBL848899

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Half-life period for disappearance of Sulbactam from rat. 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL639066

实验名称：Area under curve (AUC) was determined 来源：ChEMBL 靶标：N/A External Id：CHEMBL626148

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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舒巴坦匹酯英文别名

• Hydroxymethyl (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Pivalate (Ester) 4,4-Dioxide
• sulbactam pivaloyl-oxymethyl ester
• (2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 4,4-Dioxide (2,2-Dimethyl-1-oxopropoxy)methyl Ester
• SULBACTAM PIVOXIL
• Sulbactam pivoxyl
• 1,1-dioxopenicillanic acid pivaloyloxymethyl ester
• [(2,2-Dimethylpropanoyl)oxy]methyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
• Pivsulbactam
• Pivoxil sulbactam