异山竹子素

• 常用名: 异山竹子素
• 英文名: Isogarcinol
• CAS号: 71117-97-0
• 分子量: 602.80
• 密度: 1.2±0.1 g/cm3
• 沸点: 710.2±60.0 °C at 760 mmHg
• 分子式: C₃₈H₅₀O₆
• 熔点: N/A
• 闪点: 213.4±26.4 °C

异山竹子素用途

异没食子酸醇(Cambogin)是一种强效AChE和BChE抑制剂,其IC50值分别为1.13和8.30μM。异加西诺还显示出杀利什曼原虫的活性,对杜氏乳杆菌的IC50为0.33μM[1]。

异山竹子素名称

• 中文名: 异山竹子素
• 英文名: Isogarcinol

异山竹子素生物活性

• 描述: 异没食子酸醇(Cambogin)是一种强效AChE和BChE抑制剂,其IC50值分别为1.13和8.30μM。异加西诺还显示出杀利什曼原虫的活性,对杜氏乳杆菌的IC50为0.33μM[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 神经信号通路 >> 疼痛
• 靶点实验:

  AChE:1.13 ± 0.0 μM (IC50)

  BChE:8.30 ± 0.0 μM (IC50)

  Leishmania:0.33 μM (IC50)

• 参考文献:

  [1]. Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57.

异山竹子素物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 710.2±60.0 °C at 760 mmHg
• 分子式: C₃₈H₅₀O₆
• 分子量: 602.80
• 闪点: 213.4±26.4 °C
• 精确质量: 602.360718
• LogP: 11.07
• InChIKey: KXTNVBQRLRYVCO-LPSZMIQCSA-N
• SMILES: CC(C)=CCC1CC23CC(CC=C(C)C)C(C)(C)C(CC=C(C)C)(C(=O)C(C(=O)c4ccc(O)c(O)c4)=C2OC1(C)C)C3=O
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.579
• 储存条件: 室温

异山竹子素靶点实验

查看更多实验

实验名称：Thermodynamic equilibrium solubility, log S of the compound in simulated gastric flui... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3405572

实验名称：Thermodynamic equilibrium solubility, log S of the compound in simulated intestinal f... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3405573

实验名称：Thermodynamic equilibrium solubility, log S of the compound in water at RT after 4 hr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3405570

实验名称：Thermodynamic equilibrium solubility, log S of the compound in PBS at pH 7.4 at RT af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3405571

实验名称：Antiproliferative activity against HEL cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：HEL External Id：CHEMBL4384782

实验名称：Thermodynamic equilibrium solubility, log S of the compound simulated gastric fluid a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3405576

实验名称：Antiproliferative activity against human K562 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：K562 External Id：CHEMBL4384783

实验名称：Thermodynamic equilibrium solubility, log S of the compound simulated intestinal flui... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3405577

实验名称：Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：HeLa External Id：CHEMBL4384784

实验名称：Thermodynamic equilibrium solubility, log S of the compound in water at RT after 24 h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3405574

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异山竹子素英文别名

• Isogarcinol
• iso-Xanthochymol
• (1S,3S,9R,11R)-7-(3,4-Dihydroxybenzoyl)-4,4,10,10-tetramethyl-3,9,11-tris(3-methyl-2-buten-1-yl)-5-oxatricyclo[7.3.1.01,6]tridec-6-ene-8,13-dione