HP210

• 常用名: HP210
• 英文名: HP210
• CAS号: 728039-52-9
• 分子量: 421.54
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₉N₃O₂S₂
• 熔点: N/A
• 闪点: N/A

HP210用途

HP210是一种选择性糖皮质激素受体调节剂(SGRM)。HP210可抑制IL-1β和IL-6的mRNA表达。HP210具有研究炎症相关疾病的潜力[1]。

HP210名称

• 英文名: HP210

HP210生物活性

• 描述: HP210是一种选择性糖皮质激素受体调节剂(SGRM)。HP210可抑制IL-1β和IL-6的mRNA表达。HP210具有研究炎症相关疾病的潜力[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
• 参考文献:

  [1]. Hu X, et al. Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure- and IGN-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem. 2022 Jul 5;237:114382.

HP210物理化学性质

• 分子式: C₂₂H₁₉N₃O₂S₂
• 分子量: 421.54
• InChIKey: AJJBGZJAGZSMJI-UHFFFAOYSA-N
• SMILES: CC(NC(=O)c1ccc(Cn2c(=S)[nH]c3ccsc3c2=O)cc1)c1ccccc1

HP210靶点实验

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实验名称：Anti-inflammatory activity against human A549 cells transfected with siGR assessed as... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5123339

实验名称：Agonist activity at progesterone receptor (unknown origin) expressed in PC3 cells co-... 来源：ChEMBL 靶标：Progesterone receptor External Id：CHEMBL5123340

实验名称：Agonist activity at mineralocorticoid receptor (unknown origin) expressed in HEK293T ... 来源：ChEMBL 靶标：Mineralocorticoid receptor External Id：CHEMBL5123341

实验名称：Induction of osteoporosis in human MG-63 cells assessed as decrease in OPG mRNA expre... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5123342

实验名称：Transactivation at glucocorticoid receptor in human HeLa-MMTV-Luc cells incubated for... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL5123336

实验名称：Induction of glucocorticoid receptor nuclear translocation in human A549 cells incuba... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL5123337

实验名称：Anti-inflammatory activity against human A549 cells assessed as reduction in TNFalpha... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5123338

实验名称：Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5123331

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at ... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5123332

实验名称：Inhibition of NF-kappaB transcriptional activity in human HeLa cells transfected with... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5123333

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