Macbecin I

• 常用名: Macbecin I
• 英文名: Macbecin I
• CAS号: 73341-72-7
• 分子量: 558.66300
• 密度: 1.17g/cm3
• 沸点: 736.2ºC at 760 mmHg
• 分子式: C₃₀H₄₂N₂O₈
• 熔点: N/A
• 闪点: 399ºC

Macbecin I用途

Macbecin是一种稳定的HSP90抑制剂,通过与ATP结合位点结合,IC50为2μM,Kd为0.24μM。Macbecin具有抗肿瘤和杀细胞活性[1]。

Macbecin I名称

• 英文名: Macbecin I,(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin

Macbecin I生物活性

• 描述: Macbecin是一种稳定的HSP90抑制剂,通过与ATP结合位点结合,IC50为2μM,Kd为0.24μM。Macbecin具有抗肿瘤和杀细胞活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> HSP
  信号通路 >> 细胞周期/DNA损伤 >> HSP
• 靶点实验:

  HSP90:2 μM (IC50)

  HSP90:0.24 μM (Kd)

• 参考文献:

  [1]. Martin CJ, et al. Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem. 2008 May 8;51(9):2853-7.

Macbecin I物理化学性质

• 密度: 1.17g/cm3
• 沸点: 736.2ºC at 760 mmHg
• 分子式: C₃₀H₄₂N₂O₈
• 分子量: 558.66300
• 闪点: 399ºC
• 精确质量: 558.29400
• PSA: 143.25000
• LogP: 4.36350
• InChIKey: PLTGBUPHJAKFMA-FYJPNMAESA-N
• SMILES: COC1CC(C)C(OC)C2=CC(=O)C=C(NC(=O)C(C)=CC=CC(C)C(OC(N)=O)C(C)=CC(C)C1OC)C2=O
• 折射率: 1.545

Macbecin I毒性和生态

Macbecin I靶点实验

查看更多实验

实验名称：Antitumor activity against human DU145 tumor xenografted mouse assessed delay for tum... 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL987013

实验名称：Antitumor activity against human DU145 tumor xenografted mouse assessed delay for tum... 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL987012

实验名称：Toxicity in human DU145 cells xenografted mouse assessed as loss of body weight at 10... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL987014

实验名称：Degradation of ErbB2 in human DU145 cell lysate by Western blot 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL987009

实验名称：Experimentally measured binding affinity data (Kd) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Kd for protein-ligand complexes

实验名称：Antitumor activity against human UXL 1138L cells 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL987008

实验名称：Antitumor activity against human DU145 tumor xenografted mouse at 10 mg/kg, ip measur... 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL987011

实验名称：Degradation of cRaf1 in human DU145 cell lysate by Western blot 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL987010

实验名称：Antitumor activity against human CNXF 498NL cells 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL984368

实验名称：Antitumor activity against human BXF T24 cells 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL984367

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Macbecin I英文别名

• macbecin I