雷酚内酯

• 常用名: 雷酚内酯
• 英文名: Triptophenolide
• CAS号: 74285-86-2
• 分子量: 312.403
• 密度: 1.2±0.1 g/cm3
• 沸点: 490.0±45.0 °C at 760 mmHg
• 分子式: C₂₀H₂₄O₃
• 熔点: 232-233ºC
• 闪点: 202.4±21.5 °C

雷酚内酯用途

雷酚内酯 (Triptophenolide) 是从雷公藤的乙酸乙酯萃取部位分离到的一种无色晶体,

雷酚内酯名称

• 中文名: 雷酚内酯
• 英文名: 6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e][2]benzofuran-1-one
• 中文别名: 毛两面针素(飞龙掌血内酯)

雷酚内酯生物活性

• 描述: 雷酚内酯 (Triptophenolide) 是从雷公藤的乙酸乙酯萃取部位分离到的一种无色晶体,
• 相关类别:
  信号通路 >> 其他 >> 雄激素受体
  研究领域 >> 其他
  天然产物 >> 萜类化合物和糖苷
• 参考文献:

  [1]. XU bin, et al. Study on polarographic catalytic wave of triptophenolide. Chinese Journal of Analysis Laboratory, 2005-04

  [2]. Yang Jun, et al. Studies on Antiinflammatory and Immune Effects of Triptophenolide. Chinese Traditional and Herbal Drugs, 1995-01

雷酚内酯物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 490.0±45.0 °C at 760 mmHg
• 熔点: 232-233ºC
• 分子式: C₂₀H₂₄O₃
• 分子量: 312.403
• 闪点: 202.4±21.5 °C
• 精确质量: 312.172546
• PSA: 46.53000
• LogP: 3.92
• InChIKey: KPXIBWGPZSPABK-FXAWDEMLSA-N
• SMILES: CC(C)c1ccc2c(c1O)CCC1C3=C(CCC21C)C(=O)OC3
• 外观性状: 白色粉末
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.603
• 储存条件: -20°C

雷酚内酯安全信息

• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S36/37

雷酚内酯靶点实验

查看更多实验

实验名称：Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 72 hr... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3864024

实验名称：Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 72 hrs ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3864025

实验名称：Antagonist activity at AR in human LNCAP cells assessed as downregulation of AR prote... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL3864027

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Antagonist activity at AR in human LNCAP cells assessed as downregulation of PSA mRNA... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL3864022

实验名称：Antagonist activity at AR in human LNCAP cells assessed as downregulation of PSA mRNA... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL3864023

实验名称：Spectrum HTS for Inhibitors of Aerobactin Synthetase IucA 来源：23265 靶标：IucA Synthetase from hypervirulent Klebsiella pneumoniae hvKP1 External Id：IucA Pilot Assay Spectrum Library

实验名称：Inhibition of DHT-induced AR nuclear translocation in human LNCAP cells assessed as r... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL3864028

实验名称：Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B3 External Id：CHEMBL3039491

实验名称：The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre... 来源：11924 靶标：N/A External Id：CGM data for Cell Systems paper Dec 2015

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雷酚内酯英文别名

• Triptophenolide
• 6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e]isobenzofuran-1-one
• (3bR,9bS)-6-Hydroxy-7-isopropyl-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[1,2-c]furan-1(3H)-one