Triptophenolide
Modify Date: 2026-07-02 07:22:25
Triptophenolide structure
|
Common Name | Triptophenolide | ||
|---|---|---|---|---|
| CAS Number | 74285-86-2 | Molecular Weight | 312.403 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 490.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H24O3 | Melting Point | 232-233ºC | |
| MSDS | N/A | Flash Point | 202.4±21.5 °C | |
Use of TriptophenolideTriptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value:Target:In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1].In vivo: |
| Name | 6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e][2]benzofuran-1-one |
|---|---|
| Synonym | More Synonyms |
| Description | Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value:Target:In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1].In vivo: |
|---|---|
| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 490.0±45.0 °C at 760 mmHg |
| Melting Point | 232-233ºC |
| Molecular Formula | C20H24O3 |
| Molecular Weight | 312.403 |
| Flash Point | 202.4±21.5 °C |
| Exact Mass | 312.172546 |
| PSA | 46.53000 |
| LogP | 3.92 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.603 |
| InChIKey | KPXIBWGPZSPABK-FXAWDEMLSA-N |
| SMILES | CC(C)c1ccc2c(c1O)CCC1C3=C(CCC21C)C(=O)OC3 |
| Storage condition | -20°C |
|
~10%
Triptophenolide CAS#:74285-86-2 |
| Literature: Journal of Organic Chemistry, , vol. 65, # 7 p. 2208 - 2217 |
|
~%
Triptophenolide CAS#:74285-86-2 |
| Literature: Journal of Organic Chemistry, , vol. 65, # 7 p. 2208 - 2217 |
|
~%
Triptophenolide CAS#:74285-86-2 |
| Literature: Journal of Organic Chemistry, , vol. 65, # 7 p. 2208 - 2217 |
|
~%
Triptophenolide CAS#:74285-86-2 |
| Literature: Journal of Organic Chemistry, , vol. 65, # 7 p. 2208 - 2217 |
|
Name: Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 72 hr...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3864024
|
|
Name: Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 72 hrs ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3864025
|
|
Name: Antagonist activity at AR in human LNCAP cells assessed as downregulation of AR prote...
Source: ChEMBL
Target: Androgen receptor
External Id: CHEMBL3864027
|
|
Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
|
|
Name: Antagonist activity at AR in human LNCAP cells assessed as downregulation of PSA mRNA...
Source: ChEMBL
Target: Androgen receptor
External Id: CHEMBL3864022
|
|
Name: Antagonist activity at AR in human LNCAP cells assessed as downregulation of PSA mRNA...
Source: ChEMBL
Target: Androgen receptor
External Id: CHEMBL3864023
|
|
Name: Spectrum HTS for Inhibitors of Aerobactin Synthetase IucA
Source: 23265
Target: IucA Synthetase from hypervirulent Klebsiella pneumoniae hvKP1
External Id: IucA Pilot Assay Spectrum Library
|
|
Name: Inhibition of DHT-induced AR nuclear translocation in human LNCAP cells assessed as r...
Source: ChEMBL
Target: Androgen receptor
External Id: CHEMBL3864028
|
|
Name: Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B3
External Id: CHEMBL3039491
|
|
Name: The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre...
Source: 11924
Target: N/A
External Id: CGM data for Cell Systems paper Dec 2015
|
Total 40, Current Page 1 of 4
1
2
3
4
| Triptophenolide |
| 6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e]isobenzofuran-1-one |
| (3bR,9bS)-6-Hydroxy-7-isopropyl-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[1,2-c]furan-1(3H)-one |