Triptophenolide

Modify Date: 2025-08-20 22:20:48

Triptophenolide Structure
Triptophenolide structure
 Common Name Triptophenolide
CAS Number 74285-86-2 Molecular Weight 312.403
Density 1.2±0.1 g/cm3 Boiling Point 490.0±45.0 °C at 760 mmHg
Molecular Formula C20H24O3 Melting Point 232-233ºC
MSDS N/A Flash Point 202.4±21.5 °C

 Use of Triptophenolide


Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value:Target:In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1].In vivo:

 Names

Name 6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e][2]benzofuran-1-one
Synonym More Synonyms

 Triptophenolide Biological Activity

Description Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value:Target:In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1].In vivo:
Related Catalog
References

[1]. XU bin, et al. Study on polarographic catalytic wave of triptophenolide. Chinese Journal of Analysis Laboratory, 2005-04

[2]. Yang Jun, et al. Studies on Antiinflammatory and Immune Effects of Triptophenolide. Chinese Traditional and Herbal Drugs, 1995-01

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 490.0±45.0 °C at 760 mmHg
Melting Point 232-233ºC
Molecular Formula C20H24O3
Molecular Weight 312.403
Flash Point 202.4±21.5 °C
Exact Mass 312.172546
PSA 46.53000
LogP 3.92
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.603
Storage condition -20°C

 Safety Information

Risk Phrases R20/21/22
Safety Phrases S36/37

 Synonyms

Triptophenolide
Phenanthro[1,2-c]furan-1(3H)-one, 3b,4,5,9b,10,11-hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)-, (3bR,9bS)-
6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e]isobenzofuran-1-one
(3bR,9bS)-6-Hydroxy-7-isopropyl-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[1,2-c]furan-1(3H)-one
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