UBP 296

• 常用名: UBP 296
• 英文名: UBP 296
• CAS号: 745055-86-1
• 分子量: 333.30
• 密度: 1.5±0.1 g/cm3
• 沸点: 603.0±65.0 °C at 760 mmHg
• 分子式: C₁₅H₁₅N₃O₆
• 熔点: N/A
• 闪点: 318.5±34.3 °C

UBP 296用途

UBP296是脊髓内含有GLUK5的红藻氨酸受体的有效和选择性拮抗剂。UBP296可逆地阻断ATPA诱导的突触传递抑制,并直接影响大鼠海马脑片中AMPA受体介导的突触传递[1]。

UBP 296名称

• 英文名: 2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid

UBP 296生物活性

• 描述: UBP296是脊髓内含有GLUK5的红藻氨酸受体的有效和选择性拮抗剂。UBP296可逆地阻断ATPA诱导的突触传递抑制,并直接影响大鼠海马脑片中AMPA受体介导的突触传递[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> iGluR
• 靶点实验:

  IC50: 3.5 ± 1.5 μM (GLUK5), 4.0 ± 0.7 μM (GLUK5/GLUK6), 7.0 ± 5.1 μM (GLUK5/GLUK2)[1]

• 参考文献:

  [1]. More JC, et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 2004 Jul;47(1):46-64.

UBP 296物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 603.0±65.0 °C at 760 mmHg
• 分子式: C₁₅H₁₅N₃O₆
• 分子量: 333.30
• 闪点: 318.5±34.3 °C
• 精确质量: 333.096100
• LogP: 1.58
• InChIKey: UUIYULWYHDSXHL-UHFFFAOYSA-N
• SMILES: NC(Cn1ccc(=O)n(Cc2ccccc2C(=O)O)c1=O)C(=O)O
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.659

UBP 296靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Antagonism on GLUK5 containing kainate induced depolarization of isolated neonatal ra... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, kainate 1 External Id：CHEMBL862719

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Antagonist activity on AMPA receptor expressed on rat motoneurons by its ability to r... 来源：ChEMBL 靶标：Glutamate receptor 1 External Id：CHEMBL862717

实验名称：Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cells 来源：ChEMBL 靶标：Glutamate receptor ionotropic, kainate 3 External Id：CHEMBL862731

实验名称：Displacement of [3H]kainate from rat GLUK6 receptor expressed in HEK293 cells 来源：ChEMBL 靶标：Glutamate receptor ionotropic, kainate 2 External Id：CHEMBL862730

实验名称：Displacement of [3H]SYM2081 from kainate receptor in rat brain membrane 来源：ChEMBL 靶标：Glutamate receptor 1 External Id：CHEMBL862729

实验名称：Displacement of [3H](S)-5-fluorowillardiine from AMPA receptor in rat brain membrane 来源：ChEMBL 靶标：Glutamate receptor 1 External Id：CHEMBL862728

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UBP 296英文别名

• 2-{[3-(2-Amino-2-carboxyethyl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]methyl}benzoic acid
• 2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid
• 2-{[3-(2-Amino-2-carboxyethyl)-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]methyl}benzoic acid