Crinecerfont

• 常用名: Crinecerfont
• 英文名: SSR125543
• CAS号: 752253-39-7
• 分子量: 483.04000
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₈ClFN₂OS
• 熔点: N/A
• 闪点: N/A

Crinecerfont用途

Crinecerfont(SSR-125543)盐酸盐是一种口服有效的非肽CRF1受体拮抗剂。Crinecerfont可用于经典的先天性肾上腺增生症(CAH)研究[1]。

Crinecerfont名称

• 英文名: 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine

Crinecerfont生物活性

• 描述: Crinecerfont(SSR-125543)盐酸盐是一种口服有效的非肽CRF1受体拮抗剂。Crinecerfont可用于经典的先天性肾上腺增生症(CAH)研究[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> CFTR
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50: CRF1 receptor

• 参考文献:

  [1]. Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia (CAHtalyst).

Crinecerfont物理化学性质

• 分子式: C₂₇H₂₈ClFN₂OS
• 分子量: 483.04000
• 精确质量: 482.15900
• PSA: 53.60000
• LogP: 7.51740
• InChIKey: IEAKXXNRGSLYTQ-DEOSSOPVSA-N
• SMILES: C#CCN(c1nc(-c2cc(C)c(OC)cc2Cl)c(C)s1)C(CC1CC1)c1ccc(C)c(F)c1

Crinecerfont靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Confirmatory Screen for Target Class Profiling of Small Molecule Inhibitors of Methyl... 来源：NCGC External Id：MTASE-f-cherrypicks

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

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