1,4-双((3,5-二氯吡啶-2-基)氧基)苯结构式
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常用名 | 1,4-双((3,5-二氯吡啶-2-基)氧基)苯 | 英文名 | TCPOBOP |
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CAS号 | 76150-91-9 | 分子量 | 402.05900 | |
密度 | 1.518g/cm3 | 沸点 | 444.8ºC at 760 mmHg | |
分子式 | C16H8Cl4N2O2 | 熔点 | N/A | |
MSDS | 中文版 美版 | 闪点 | 222.8ºC |
1,4-双((3,5-二氯吡啶-2-基)氧基)苯用途TCPOBOP 是一种组成型雄甾烷受体 (CAR) 激动剂,可诱导强健的肝细胞增殖和肝肿大,无任何肝损伤或组织缺失。TCPOBOP 通过改变 Bcl-2 蛋白减弱 Fas 诱导的小鼠肝损伤。 |
中文名 | 1,4-双((3,5-二氯吡啶-2-基)氧基)苯 |
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英文名 | 3,5-dichloro-2-[4-(3,5-dichloropyridin-2-yl)oxyphenoxy]pyridine |
英文别名 | 更多 |
描述 | TCPOBOP 是一种组成型雄甾烷受体 (CAR) 激动剂,可诱导强健的肝细胞增殖和肝肿大,无任何肝损伤或组织缺失。TCPOBOP 通过改变 Bcl-2 蛋白减弱 Fas 诱导的小鼠肝损伤。 |
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相关类别 | |
靶点 |
Bcl-2 |
体内研究 | TCPOBOP(口服;3mg/kg;1-5天)在48小时时显著增加LW/BW比率中的肝脏重量与体重[1]。动物模型:MET fl/fl:靶向缺失MET KO外显子16的Tam-Cre +/+小鼠[1]剂量:3mg/kg给药:口服;1,2,5天结果:肝脏重量增加至体重。 |
参考文献 |
密度 | 1.518g/cm3 |
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沸点 | 444.8ºC at 760 mmHg |
分子式 | C16H8Cl4N2O2 |
分子量 | 402.05900 |
闪点 | 222.8ºC |
精确质量 | 399.93400 |
PSA | 44.24000 |
LogP | 6.67480 |
折射率 | 1.635 |
储存条件 | 2-8°C,干燥,密封 |
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