3-巯基-2苄基丙基甘氨酸

• 常用名: 3-巯基-2苄基丙基甘氨酸
• 英文名: Thiorphan
• CAS号: 76721-89-6
• 分子量: 253.32
• 密度: 1.2±0.1 g/cm3
• 沸点: 524.0±50.0 °C at 760 mmHg
• 分子式: C₁₂H₁₅NO₃S
• 熔点: 138-140ºC
• 闪点: 270.7±30.1 °C

3-巯基-2苄基丙基甘氨酸用途

噻吩是一种选择性NEP(尼泊尔溶素)抑制剂,IC50为6.9 nM【1】。

3-巯基-2苄基丙基甘氨酸名称

• 中文名: 3-巯基-2苄基丙基甘氨酸
• 英文名: 2-[(2-benzyl-3-sulfanylpropanoyl)amino]acetic acid
• 中文别名: 2-[[2-(苄基)-3-硫基丙酰]氨基]乙酸 | 2-巯基甲基-(3-苯基丙酰基氨基)-乙酸 | 塞奥芬

3-巯基-2苄基丙基甘氨酸生物活性

• 描述: 噻吩是一种选择性NEP(尼泊尔溶素)抑制剂,IC50为6.9 nM【1】。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 代谢酶/蛋白酶 >> 脑啡肽酶
• 参考文献:

  [1]. Whyteside AR, Turner AJ. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 2008 Jul 9;582(16):2382-6.

3-巯基-2苄基丙基甘氨酸物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 524.0±50.0 °C at 760 mmHg
• 熔点: 138-140ºC
• 分子式: C₁₂H₁₅NO₃S
• 分子量: 253.32
• 闪点: 270.7±30.1 °C
• 精确质量: 253.077271
• PSA: 105.20000
• LogP: 1.37
• InChIKey: LJJKNPQAGWVLDQ-UHFFFAOYSA-N
• SMILES: O=C(O)CNC(=O)C(CS)Cc1ccccc1
• 外观性状: 灰白色固体
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.577
• 储存条件: 室温

3-巯基-2苄基丙基甘氨酸安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 安全声明 (欧洲): 22-24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• 海关编码: 2930909090

3-巯基-2苄基丙基甘氨酸海关

• 海关编码: 2930909090
• 中文概述: 2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3-巯基-2苄基丙基甘氨酸靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Inhibition of recombinant human Aminopeptidase N using L-Ala-beta-NA as substrate pre... 来源：ChEMBL 靶标：Aminopeptidase N External Id：CHEMBL3631552

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Resistance index, ratio of IC50 for human KB-3-1 cells to IC50 for drug-resistant hum... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2161873

实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint... 来源：Broad Institute 靶标：N/A External Id：2084-01_Activator_SinglePoint_HTS_Activity

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3-巯基-2苄基丙基甘氨酸英文别名

• N-[(RS)-2-Benzyl-3-mercaptopropanoyl]-glycine
• DL-[N-(3-mercapto-2-benzylpropanoyl)]glycine
• Glycine,N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-,(+-)
• N-[(R,S)-3-mercapto-2-benzyl-propionyl]glycine
• DL-Thiorphan
• Tiorphan
• (2-mercaptomethyl-3-phenyl-propionylamino)-acetic acid
• N-(2-Benzyl-3-sulfanylpropanoyl)glycine
• DL-3-Mercapto-2-benzylpropanoylglycine
• Prestwick_694
• N-(3-mercapto-2-benzylpropanoyl)glycine
• (2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE
• (3-Mercapto-2-benzylpropionyl)glycine
• Thiorphan