依尼前列素

• 常用名: 依尼前列素
• 英文名: SC 34301
• CAS号: 81026-63-3
• 分子量: 380.51800
• 密度: 1.092g/cm3
• 沸点: 490.2ºC at 760 mmHg
• 分子式: C₂₂H₃₆O₅
• 熔点: N/A
• 闪点: 158.2ºC

依尼前列素用途

SC 34301(Enisoropost)是一种强效口服活性PGE1类似物。SC 34301显著减少了细菌易位,提高了烧伤小鼠的存活率[1][2]。

依尼前列素名称

• 中文名: 依尼前列素
• 英文名: enisoprost

依尼前列素生物活性

• 描述: SC 34301(Enisoropost)是一种强效口服活性PGE1类似物。SC 34301显著减少了细菌易位,提高了烧伤小鼠的存活率[1][2]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
• 体内研究: SC 34301(200µg/kg；口服；每天一次,持续三天)显着减少细菌移位并提高存活率[1]。 动物模型：BALB/c小鼠(大肠杆菌,烧伤)[1]剂量：200µg/kg给药：口服。；结果：通过血液dpm计数测量,显著降低了细菌易位的程度,将烧伤小鼠的存活率提高到60%。
• 参考文献:

  [1]. Pollak R, et al. A trial of the prostaglandin E1 analogue, enisoprost, to reverse chronic cyclosporine-associated renal dysfunction. Am J Kidney Dis. 1992 Oct;20(4):336-41.

  [2]. Fukushima R, et al. The degree of bacterial translocation is a determinant factor for mortality after burn injury and is improved by prostaglandin analogs. Ann Surg. 1992 Oct;216(4):438-44; discussion 444-5.

依尼前列素物理化学性质

• 密度: 1.092g/cm3
• 沸点: 490.2ºC at 760 mmHg
• 分子式: C₂₂H₃₆O₅
• 分子量: 380.51800
• 闪点: 158.2ºC
• 精确质量: 380.25600
• PSA: 83.83000
• LogP: 3.72960
• InChIKey: CIBHDGPIOICRGX-ZQCHCGQNSA-N
• SMILES: CCCCC(C)(O)CC=CC1C(O)CC(=O)C1CCC=CCCC(=O)OC
• 折射率: 1.536

依尼前列素靶点实验

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实验名称：Relative gastric antisecretory effect in histamine-stimulated Heidenhain Pouch (HP) d... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL672828

实验名称：Ratio of ED50 value of diarrheal effect to that of ED50 value of antisecretory effect 来源：ChEMBL 靶标：N/A External Id：CHEMBL851310

实验名称：Ratio of ED50 of diarrheal effect to antisecretory effect 来源：ChEMBL 靶标：N/A External Id：CHEMBL851137

实验名称：Antisecretory activity after iv administration in histamine-stimulated Heidenhain pou... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL884427

实验名称：Activity for diarrheagenic effect in rats by intragastric administration and the valu... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL779796

实验名称：Diarrheal effect after ig administration in rats 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL780962

实验名称：Compound was evaluated for diarrheagenic side effects in adult male rats by intragast... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL783762

实验名称：Activity for gastric antisecretory activity in dogs by intrapouch administration and ... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL669710

实验名称：Oral gastric antisecretory effect in histamine-stimulated Heidenhain Pouch (HP) dogs 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL671105

实验名称：Selectivity ratio was evaluated by the quotient of diarrheal ED50 value divided by an... 来源：ChEMBL 靶标：N/A External Id：CHEMBL847410

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依尼前列素英文别名

• Prosta-4,13-dien-1-oic acid,11,16-dihydroxy-16-methyl-9-oxo-,methyl ester,(4Z,11alpha,13E)-(+-)