JNJ-17203212

• 常用名: JNJ-17203212
• 英文名: JNJ 17203212
• CAS号: 821768-06-3
• 分子量: 419.32400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₅F₆N₅O
• 熔点: N/A
• 闪点: N/A
• 符号: GHS06
• 信号词: Danger

JNJ-17203212用途

JNJ-17203212是一种新型的选择性TRPV1拮抗剂，作用于人和大鼠TRPV1，IC50 值分别为65 nM和 102 nM。

JNJ-17203212名称

• 中文名: JNJ-17203212
• 英文名: 4-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide

JNJ-17203212生物活性

• 描述: JNJ-17203212是一种新型的选择性TRPV1拮抗剂,作用于人和大鼠TRPV1,IC50 值分别为65 nM和 102 nM。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Wiskur BJ, et al. A novel TRPV1 receptor antagonist JNJ-17203212 attenuates colonic hypersensitivity in rats. Methods Find Exp Clin Pharmacol. 2010 Oct;32(8):557-64.

  [2]. Swanson DM, et al. Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. J Med Chem. 2005 Mar 24;48(6):185

JNJ-17203212物理化学性质

• 分子式: C₁₇H₁₅F₆N₅O
• 分子量: 419.32400
• 精确质量: 419.11800
• PSA: 61.36000
• LogP: 3.94420
• InChIKey: JFRYYGVYCWYIDQ-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccc(C(F)(F)F)cn1)N1CCN(c2ncccc2C(F)(F)F)CC1
• 储存条件: 2-8℃

JNJ-17203212安全信息

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301-H319
• 警示性声明: P301 + P310-P305 + P351 + P338
• 危险品运输编码: UN 2811 6.1 / PGIII

JNJ-17203212靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

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JNJ-17203212英文别名

• unii-71je0c439x
• JNJ-17203212