SN 2

• 常用名: SN 2
• 英文名: SN 2
• CAS号: 823218-99-1
• 分子量: 255.355
• 密度: 1.3±0.1 g/cm3
• 沸点: 370.8±52.0 °C at 760 mmHg
• 分子式: C₁₇H₂₁NO
• 熔点: N/A
• 闪点: 144.5±23.2 °C

SN 2用途

SN 2 是一种有效的 TRPML3 离子通道激活剂,EC50 为 1.8±0.13 μM。

SN 2名称

• 中文名: SN 2
• 英文名: SN 2

SN 2生物活性

• 描述: SN 2 是一种有效的 TRPML3 离子通道激活剂,EC50 为 1.8±0.13 μM。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 其他
• 靶点实验:

  EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)[1]

• 体外研究: 估计TRPML3通道的电导,当用10μM激活时,SN-2在-80mV下约为10pS。表达TRPML3的HEK293细胞用单独的化合物(在SBS中)开始灌注,在ELS中用化合物,最后用ELS单独灌注。测试了两种代表性化合物SF-24和SN-2。 SF-24是效果最差的化合物之一,SN-2是最活跃的化合物之一。 SN-2具有类似的协同效应,与个体响应相比,组合响应也达到10倍的增强,在-80mV达到平均电流密度高达3nA/pF。显性负性TRPML3(D458K)在消除表皮黑素细胞中SN-2诱导的活性方面非常有效,表明SN-2激活在TRPML3(D458K)存在下不响应的通道。这种显性负面作用可能归因于TRPML3(D458K)与SN-2反应通道的潜在异构化[1]。
• 参考文献:

  [1]. Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48.

SN 2物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 370.8±52.0 °C at 760 mmHg
• 分子式: C₁₇H₂₁NO
• 分子量: 255.355
• 闪点: 144.5±23.2 °C
• 精确质量: 255.162308
• LogP: 4.25
• InChIKey: WKLZNTYMDOPBSE-UHFFFAOYSA-N
• SMILES: Cc1cc(C)c(C2=NOC3C4CCC(C4)C23)c(C)c1
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.665
• 储存条件: 2-8℃

SN 2靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Human TRPML3 (Transient Receptor Potential channels) 来源：IUPHAR-DB 靶标：TRPML3 (Transient Receptor Potential channels) [Homo sapiens] External Id：503_Human

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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SN 2英文别名

• 5-Mesityl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene
• MFCD05739166
• MFCD09266779