A 784168

• 常用名: A 784168
• 英文名: A 784168
• CAS号: 824982-41-4
• 分子量: 479.39600
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₅F₆N₃O₃S
• 熔点: N/A
• 闪点: N/A

A 784168用途

A-784168是一种口服有效的香草醛受体1型(TRPV1)抑制剂。香草醛受体1型(TRPV1)是一种配体门控的非选择性阳离子通道,被认为是各种疼痛刺激(如内源性脂质、辣椒素、热量和低pH值)的重要整合物。a-784168具有良好的中枢神经系统渗透性【1】。

A 784168名称

• 英文名: 3'-(Trifluoromethyl)-N-(4-((trifluoromethyl)sulfonyl)phenyl)-3,6-dihydro-2H-[1,2'-bipyridine]-4-carboxamide

A 784168生物活性

• 描述: A-784168是一种口服有效的香草醛受体1型(TRPV1)抑制剂。香草醛受体1型(TRPV1)是一种配体门控的非选择性阳离子通道,被认为是各种疼痛刺激(如内源性脂质、辣椒素、热量和低pH值)的重要整合物。a-784168具有良好的中枢神经系统渗透性【1】。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Cui M, et al. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J Neurosci. 2006;26(37):9385-9393.

A 784168物理化学性质

• 分子式: C₁₉H₁₅F₆N₃O₃S
• 分子量: 479.39600
• 精确质量: 479.07400
• PSA: 87.75000
• LogP: 5.38790
• InChIKey: SDUAWRFBHRAFBM-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccc(S(=O)(=O)C(F)(F)F)cc1)C1=CCN(c2ncccc2C(F)(F)F)CC1

A 784168靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Radioligand Binding Assay and Antagonist Ca2+ Influx Functional Assay from Article 10... 来源：BindingDB 靶标：N/A External Id：BindingDB_2429_2

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Analgesic activity against complete Freund's adjuvant-induced thermal hyperalgesia in... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL990782

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Antinociceptive activity against hyperalgesia in po dosed rat Chung neuropathic pain ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL990781

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

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