A 784168

Modify Date: 2024-04-09 15:13:34

A 784168 Structure
A 784168 structure
Common Name A 784168
CAS Number 824982-41-4 Molecular Weight 479.39600
Density N/A Boiling Point N/A
Molecular Formula C19H15F6N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of A 784168


A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration[1].

 Names

Name 3'-(Trifluoromethyl)-N-(4-((trifluoromethyl)sulfonyl)phenyl)-3,6-dihydro-2H-[1,2'-bipyridine]-4-carboxamide

 A 784168 Biological Activity

Description A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration[1].
Related Catalog
References

[1]. Cui M, et al. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J Neurosci. 2006;26(37):9385-9393.

 Chemical & Physical Properties

Molecular Formula C19H15F6N3O3S
Molecular Weight 479.39600
Exact Mass 479.07400
PSA 87.75000
LogP 5.38790
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