土槿甲酸甲酯 B

• 常用名: 土槿甲酸甲酯 B
• 英文名: Methylpseudolarate B
• CAS号: 82508-34-7
• 分子量: 402.481
• 密度: 1.2±0.1 g/cm3
• 沸点: 528.8±50.0 °C at 760 mmHg
• 分子式: C₂₃H₃₀O₆
• 熔点: N/A
• 闪点: 228.0±30.2 °C

土槿甲酸甲酯 B用途

伪酒石酸甲酯B是一种天然二萜,是一种蛋白质酪氨酸磷酸酶1B(PTP1B)(磷酸酶)抑制剂,IC50值为10.9μM[1]。

土槿甲酸甲酯 B名称

• 中文名: 土槿甲酸甲酯 B
• 英文名: Methyl (1R,7S,8S,9R)-7-acetoxy-9-[(1E,3E)-5-methoxy-4-methyl-5-oxo-1,3-pentadien-1-yl]-9-methyl-11-oxo-10-oxatricyclo[6.3.2.01,7]tridec-3-ene-4-carboxylate

土槿甲酸甲酯 B生物活性

• 描述: 伪酒石酸甲酯B是一种天然二萜,是一种蛋白质酪氨酸磷酸酶1B(PTP1B)(磷酸酶)抑制剂,IC50值为10.9μM[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50: 10.9 μM (PTP1B)[1]

• 参考文献:

  [1]. Chun Lei, et al. New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis. Fitoterapia. 2019 Nov;139:104414.

土槿甲酸甲酯 B物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 528.8±50.0 °C at 760 mmHg
• 分子式: C₂₃H₃₀O₆
• 分子量: 402.481
• 闪点: 228.0±30.2 °C
• 精确质量: 402.204254
• PSA: 105.20000
• LogP: 4.00
• InChIKey: DXNRJQIZAXOHQJ-KYNXZXPVSA-N
• SMILES: COC(=O)C(C)=CC=CC1(C)OC(=O)C23CC=C(C(=O)OC)CCC2(OC(C)=O)C1CC3
• 外观性状: 油状物体
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.543
• 储存条件: 2-8℃，干燥，密闭

土槿甲酸甲酯 B安全信息

• 危害码 (欧洲): Xi

土槿甲酸甲酯 B靶点实验

查看更多实验

实验名称：Antimicrobial activity against Mycobacterium intracellular at 1 mg/mL by agar-well di... 来源：ChEMBL 靶标：Mycobacterium intracellulare External Id：CHEMBL943216

实验名称：Antimicrobial activity against Staphylococcus aureus at 1 mg/mL by agar-well diffusio... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL943213

实验名称：Antimicrobial activity against Escherichia coli at 1 mg/mL by agar-well diffusion ass... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL943212

实验名称：Antimicrobial activity against Pseudomonas aeruginosa at 1 mg/mL by agar-well diffusi... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL943215

实验名称：Antimicrobial activity against Bacillus subtilis at 1 mg/mL by agar-well diffusion as... 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL943214

实验名称：Antimicrobial activity against Trichophyton mentagrophytes at 1 mg/mL by agar-well di... 来源：ChEMBL 靶标：Trichophyton mentagrophytes External Id：CHEMBL943209

实验名称：Antimicrobial activity against Cryptococcus neoformans at 1 mg/mL by agar-well diffus... 来源：ChEMBL 靶标：Cryptococcus neoformans External Id：CHEMBL943208

实验名称：Antimicrobial activity against Saccharomyces cerevisiae at 1 mg/mL by agar-well diffu... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL943211

实验名称：Antimicrobial activity against Microsporum gypseum at 1 mg/mL by agar-well diffusion ... 来源：ChEMBL 靶标：Nannizzia gypsea External Id：CHEMBL943210

实验名称：Antimicrobial activity against Candida albicans at 1 mg/mL by agar-well diffusion ass... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL943205

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土槿甲酸甲酯 B英文别名

• Methyl (2E,4E)-5-[(1R,7S,8S,9R)-7-acetoxy-4,9-dimethyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-en-9-yl]-2-methyl-2,4-pentadienoate
• Methyl (1R,7S,8S,9R)-7-acetoxy-9-[(1E,3E)-5-methoxy-4-methyl-5-oxo-1,3-pentadien-1-yl]-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-ene-4-carboxylate