去乙基胺碘酮

• 常用名: 去乙基胺碘酮
• 英文名: Desethylamiodarone
• CAS号: 83409-32-9
• 分子量: 617.25800
• 密度: 1.638 g/cm3
• 沸点: 630.3ºC at 760 mmHg
• 分子式: C₂₃H₂₅I₂NO₃
• 熔点: N/A
• 闪点: 335ºC

去乙基胺碘酮用途

Desethylamiodarone (N-Deethylamiodarone) 是抗心律失常化合物胺碘酮 (Amiodarone (HY-14187)) 的主要代谢物。Desethylamiodarone 具有抗心律失常活性。Desethylamiodarone 还可诱导癌细胞凋亡 (apoptosis)。

去乙基胺碘酮名称

• 中文名: 去乙基胺碘酮
• 英文名: (2-butyl-1-benzofuran-3-yl)-[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]methanone
• 中文别名: 2-丁基-3-苯并呋喃基-[4-(2-乙氨基乙氧基)-3,5-二碘苯基]甲酮

去乙基胺碘酮生物活性

• 描述: Desethylamiodarone (N-Deethylamiodarone) 是抗心律失常化合物胺碘酮 (Amiodarone (HY-14187)) 的主要代谢物。Desethylamiodarone 具有抗心律失常活性。Desethylamiodarone 还可诱导癌细胞凋亡 (apoptosis)。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Bognar Z, et al. Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways. PLoS One. 2017 Dec 8;12(12):e0189470.

  [2]. Kannan R, et al. Amiodarone toxicity. II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats. Fundam Appl Toxicol. 1991 Jan;16(1):103-9.

去乙基胺碘酮物理化学性质

• 密度: 1.638 g/cm3
• 沸点: 630.3ºC at 760 mmHg
• 分子式: C₂₃H₂₅I₂NO₃
• 分子量: 617.25800
• 闪点: 335ºC
• 精确质量: 616.99200
• PSA: 51.47000
• LogP: 6.59480
• InChIKey: VXOKDLACQICQFA-UHFFFAOYSA-N
• SMILES: CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCNCC)c(I)c1
• 折射率: 1.635

去乙基胺碘酮毒性和生态

去乙基胺碘酮靶点实验

查看更多实验

实验名称：Effect on calcium mobilization in CHO cells stably expressing Galpha16 at 10 uM relat... 来源：ChEMBL 靶标：CHO External Id：CHEMBL1048865

实验名称：Retention time of the compound by UPLC-Q/TOF mass spectrometry 来源：ChEMBL 靶标：N/A External Id：CHEMBL3535776

实验名称：TRalpha-Binding Assay. from Article 10.1210/endo.137.7.8770901: "Structure-function r... 来源：BindingDB 靶标：N/A External Id：BindingDB_2290_1

实验名称：Drug level in human liver S9 fraction assessed as compound formation treated with 50 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3533205

实验名称：Activation of human TAAR1 expressed in CHOK1 cells coexpressing Galpha16 assessed as ... 来源：ChEMBL 靶标：Trace amine-associated receptor 1 External Id：CHEMBL1048863

实验名称：Drug level in human liver S9 fraction assessed as compound formation treated with 50 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3535791

实验名称：Drug level in arrhythmia patient bile treated with amiodarone at 200 mg/day, po for 7... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3535775

实验名称：Activation of human TAAR1 expressed in CHOK1 cells assessed as cAMP accumulation at 0... 来源：ChEMBL 靶标：Trace amine-associated receptor 1 External Id：CHEMBL1048859

实验名称：Activation of human TAAR1 expressed in CHOK1 cells coexpressing Galpha16 assessed as ... 来源：ChEMBL 靶标：Trace amine-associated receptor 1 External Id：CHEMBL1048860

实验名称：TRbeta-Binding Assay from Article 10.1210/endo.137.7.8770901: "Structure-function re... 来源：BindingDB 靶标：N/A External Id：BindingDB_2290_2

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去乙基胺碘酮英文别名

• N-Desethylamiodarone
• Desethylamiodarone
• N-Deethylamiodarone
• Methanone,(2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)
• N-Monodesethylamiodarone
• (2-butyl-1-benzofuran-3-yl){4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl}methanone
• (2-Butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)methanone
• Deethylamiodarone
• Amiodarone Impurity 2