羟基-alpha-山椒醇

• 常用名: 羟基-alpha-山椒醇
• 英文名: Hydroxy-alpha-sanshool
• CAS号: 83883-10-7
• 分子量: 263.37500
• 密度: 0.973 g/cm3
• 沸点: 471.5±45.0℃ at 760 mmHg
• 分子式: C₁₆H₂₅NO₂
• 熔点: N/A
• 闪点: N/A

羟基-alpha-山椒醇用途

Hydroxy-​α-​sanshool 是从胡椒中分离到的烷基酰胺,为 TRPA1 的共价激动剂和 TRPV1 的非共价激动剂,EC50 值分别为 69 和 1.1 µM。

羟基-alpha-山椒醇名称

• 中文名: 羟基-alpha-山椒醇
• 英文名: alpha-Hydroxy-Sanshool

羟基-alpha-山椒醇生物活性

• 描述: Hydroxy-​α-​sanshool 是从胡椒中分离到的烷基酰胺,为 TRPA1 的共价激动剂和 TRPV1 的非共价激动剂,EC50 值分别为 69 和 1.1 µM。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 神经疾病
• 靶点实验:

  EC50: 69 µM (TRPA1), 1.1 µM (TRPV1)[1]

• 参考文献:

  [1]. Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157(8):1398-409.

羟基-alpha-山椒醇物理化学性质

• 密度: 0.973 g/cm3
• 沸点: 471.5±45.0℃ at 760 mmHg
• 分子式: C₁₆H₂₅NO₂
• 分子量: 263.37500
• 精确质量: 263.18900
• PSA: 49.33000
• LogP: 3.28930
• InChIKey: LHFKHAVGGJJQFF-UEOYEZOQSA-N
• SMILES: CC=CC=CC=CCCC=CC(=O)NCC(C)(C)O
• 储存条件: 2-8℃

羟基-alpha-山椒醇安全信息

• 海关编码: 2924199090

羟基-alpha-山椒醇海关

• 海关编码: 2924199090
• 中文概述: 2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 包装
• Summary: 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

羟基-alpha-山椒醇靶点实验

查看更多实验

实验名称：Selectivity ratio of IC50 for human CB1 receptor to IC50 for human CB2 receptor 来源：ChEMBL 靶标：N/A External Id：CHEMBL3089349

实验名称：Inhibition of human CB2 receptor internalization expressed in CHO cells assessed as i... 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL3089350

实验名称：Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells preincuba... 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL3089351

实验名称：Inhibition of human CB1 receptor internalization expressed in CHO cells assessed as i... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL3089352

实验名称：Displacement of [3H]-Win55212-2 from human CB1 receptor expressed in CHO cells preinc... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL3089353

实验名称：NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L... 来源：DTP/NCI 靶标：N/A External Id：MCF7_OneDose

实验名称：NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell... 来源：DTP/NCI 靶标：N/A External Id：IGROV1_OneDose

实验名称：Activation of TRPA1 channel 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily A member 1 External Id：CHEMBL1118242

实验名称：Cytotoxicity against mouse Nf1-/-;Trp53-/- KR158 cells assessed as cell viability at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2339384

实验名称：Growth inhibition of mouse Nf1-/-;Trp53-/- KR158 cells assessed as green luminescence... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2339383

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羟基-alpha-山椒醇英文别名

• (2E,6Z,8E,10E)-N-(2-HYDROXY-2-METHYL-PROPYL)DODECA-2,6,8,10-TETRAENAMIDE
• (2E,6Z,8E,10E)-N-(2-hydroxy-2-methylpropyl)dodeca-2,6,8,10-tetraenamide