阿格拉宾

• 常用名: 阿格拉宾
• 英文名: Arglabin
• CAS号: 84692-91-1
• 分子量: 246.302
• 密度: 1.2±0.1 g/cm3
• 沸点: 404.6±45.0 °C at 760 mmHg
• 分子式: C₁₅H₁₈O₃
• 熔点: 102 °C
• 闪点: 171.3±23.3 °C

阿格拉宾用途

Arglabin由亮绿蒿中提取获得的天然产物,具有抗癌活性。

阿格拉宾名称

• 中文名: Arglabin
• 英文名: arglabin

阿格拉宾生物活性

• 描述: Arglabin由亮绿蒿中提取获得的天然产物,具有抗癌活性。
• 相关类别:
  信号通路 >> 免疫及炎症 >> NOD样受体(NLR)
  研究领域 >> 癌症
  天然产物 >> 萜类化合物和糖苷
• 参考文献:

  [1]. Bottex-Gauthier C, et al. In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall. (Asteraceae). Biotechnol Ther. 1993;4(1-2):77-98.

  [2]. Abil'daeva AZh, et al. Anti-inflammatory effect of arglabin and 11,13-dihydro-13-dimethylaminoarglabin hydrochloride. Eksp Klin Farmakol. 2004 Jan-Feb;67(1):37-9.

  [3]. Zhang Q, et al. Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells. J Med Chem. 2012 Oct 25;55(20):8757-69.

阿格拉宾物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 404.6±45.0 °C at 760 mmHg
• 熔点: 102 °C
• 分子式: C₁₅H₁₈O₃
• 分子量: 246.302
• 闪点: 171.3±23.3 °C
• 精确质量: 246.125595
• PSA: 38.83000
• LogP: 1.74
• InChIKey: UVJYAKBJSGRTHA-CUZKYEQNSA-N
• SMILES: C=C1C(=O)OC2C1CCC1(C)OC13CC=C(C)C23
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.571
• 储存条件: -20°C;避免光,加热

阿格拉宾靶点实验

查看更多实验

实验名称：Cytotoxicity against human leukemia stem/progenitor cells assessed as viable CD34+CD3... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2210164

实验名称：Cytotoxicity against human leukemia stem/progenitor cells assessed as viable CD34+ ce... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2210165

实验名称：Cytotoxicity against human leukemia stem/progenitor cells assessed as viable CD34+ ce... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2210580

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-H295R-72hr

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303810

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

共33条，当前第1页，共4页

1

2

3

4

阿格拉宾英文别名

• (3aR,4aS,6aS,9aS,9bR)-1,4a-Dimethyl-7-methylene-5,6,6a,7,9a,9b-hexahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one
• (+)-Arglabin