TCO-OH结构式
|
常用名 | TCO-OH | 英文名 | TCO-OH |
|---|---|---|---|---|
| CAS号 | 85081-69-2 | 分子量 | 126.19600 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C8H14O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS05 |
信号词 | Danger |
TCO-OH用途
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TCO-OH 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。 |
| 中文名 | (E)-环辛-4-烯醇 |
|---|---|
| 英文名 | 4-Cycloocten-1-ol, (4E) |
| 英文别名 | 更多 |
| 描述 | TCO-OH 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。 |
|---|---|
| 相关类别 | |
| 靶点 |
Alkyl-Chain |
| 体外研究 | PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。 |
| 参考文献 |
| 分子式 | C8H14O |
|---|---|
| 分子量 | 126.19600 |
| 精确质量 | 126.10400 |
| PSA | 20.23000 |
| LogP | 1.86760 |
| 外观性状 | 液体 |
| 储存条件 | 20°C |
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Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.
Bioconjug. Chem. 22 , 2263-2270, (2011) 1,2,4,5-Tetrazines have been established as effective dienes for inverse electron demand [4 + 2] Diels-Alder cycloaddition reactions with strained alkenes for over 50 years. Recently, this reaction pa... |
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Tetrazine-based cycloadditions: application to pretargeted live cell imaging.
Bioconjug. Chem. 19 , 2297-2299, (2008) Bioorthogonal tetrazine cycloadditions have been applied to live cell labeling. Tetrazines react irreversibly with the strained dienophile norbornene forming dihydropyrazine products and dinitrogen. T... |
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Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.
J. Am. Chem. Soc. 130 , 13518-13519, (2008) Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives. The reactions tol... |
| (E)-CYCLOOCT-4-ENOL |
| 4-Cycloocten-1-ol, (E)- |
| (E)-Cyclooct-4-enol |
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